Abstract
The upregulation of HIV-1 co-receptor expression during certain clinical settings may explain the predisposition of individuals to enhanced HIV-1 acquisition. We sought to determine the effect of estrogen and progesterone on the HIV-1 coreceptors, CCR5 and CXCR4. Co-receptor expression on CD3- and CD14-positive cells obtained systemically and locally (genital tissue in women) was determined in men, pre- and post-menopausal women, pregnant women in each trimester and in labor. CCR5 on both CD3- and CD14-positive cells was highest in pregnant women, and increased as gestation advanced ( P <.01 and P <.001, respectively). Progesterone levels were significantly associated with CCR5 expression on PBMCs ( P <.03 for CD3-positive, and P <.002 for CD14-positive cells) and from cells isolated from tissue ( P <.001).CCR5 mRNA expression correlated with the cell surface marker expression from blood and tissue. These findings suggest that pregnancy and other high progesterone states may predispose women to HIV-1 acquisition.
Original language | English (US) |
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Pages (from-to) | 20-31 |
Number of pages | 12 |
Journal | Reproductive Sciences |
Volume | 16 |
Issue number | 1 |
DOIs | |
State | Published - Jan 2009 |
Externally published | Yes |
Keywords
- HIV acquisition
- HIV-1 coreceptor
- Progesterone
ASJC Scopus subject areas
- Obstetrics and Gynecology