The effect of preoperative chemotherapy treatment in surgically treated intrahepatic cholangiocarcinoma patients—A multi-institutional analysis

Stefan Buettner, Bas Groot Koerkamp, Aslam Ejaz, Florian E. Buisman, Yuhree Kim, Georgios Antonios Margonis, Sorin Alexandrescu, Hugo P. Marques, Jorge Lamelas, Luca Aldrighetti, T. Clark Gamblin, Shishir K. Maithel, Carlo Pulitano, Todd W. Bauer, Feng Shen, George A. Poultsides, J. Wallis Marsh, Jan N M IJzermans, Timothy M. Pawlik

Research output: Contribution to journalArticle

Abstract

INTRODUCTION: While preoperative chemotherapy (pCT) is utilized in many intra-abdominal cancers, the use of pCT among patients with intrahepatic cholangiocarcinoma (ICC) remains ill defined. As such, the objective of the current study was to examine the impact of pCT among patients undergoing curative-intent resection for ICC. METHODS: Patients who underwent hepatectomy for ICC were identified from a multi-institutional international cohort. The association between pCT with peri-operative and long-term clinical outcomes was assessed. RESULTS: Of the 1 057 patients who were identified and met the inclusion criteria, 62 patients (5.9%) received pCT. These patients were noticed to have more advanced disease. Median OS (pCT:46.9 months vs no pCT:37.4 months; P = 0.900) and DFS (pCT: 34.1 months vs no pCT: 29.1 months; P = 0.909) were similar between the two groups. In a subgroup analysis of propensity-score matched patients, there was longer OS (pCT:46.9 months vs no pCT:29.4 months) and DFS (pCT:34.1 months vs no pCT:14.0 months); however this did not reach statistical significance (both P > 0.05). CONCLUSION: In conclusion, pCT utilization among patients with ICC was higher among patients with more advanced disease. Short-term post-operative outcomes were not affected by pCT use and receipt of pCT resulted in equivalent OS and DFS following curative-intent resection.

Original languageEnglish (US)
Pages (from-to)312-318
Number of pages7
JournalJournal of Surgical Oncology
Volume115
Issue number3
DOIs
StatePublished - Mar 1 2017

Keywords

  • intrahepatic cholangiocarcinoma
  • preoperative chemotherapy
  • prognostic factors
  • risk factors
  • survival

ASJC Scopus subject areas

  • Surgery
  • Oncology

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    Buettner, S., Koerkamp, B. G., Ejaz, A., Buisman, F. E., Kim, Y., Margonis, G. A., Alexandrescu, S., Marques, H. P., Lamelas, J., Aldrighetti, L., Gamblin, T. C., Maithel, S. K., Pulitano, C., Bauer, T. W., Shen, F., Poultsides, G. A., Marsh, J. W., IJzermans, J. N. M., & Pawlik, T. M. (2017). The effect of preoperative chemotherapy treatment in surgically treated intrahepatic cholangiocarcinoma patients—A multi-institutional analysis. Journal of Surgical Oncology, 115(3), 312-318. https://doi.org/10.1002/jso.24524