The effect of positive semen bacterial and Ureaplasma cultures on in-vitro fertilization success

Sian Shalika, Kim Dugan, Rosella D. Smith, Santiago L. Padilla

Research output: Contribution to journalArticlepeer-review

Abstract

A total of 342 couples planning to undergo in-vitro fertilization (IVF) were examined for the presence of bacteria in semen prior to and during the procedure. Pregnancy rates were analysed retrospectively to ascertain any adverse affects if > 10 000 colony forming units (CFU)/ml bacteria were detected in the semen sample. The most common bacteria isolated from semen were Enterococcus spp. (73%). The presence of these bacteria did not affect the pregnancy rate of the patients with positive cultures prior to (32%) or during (37%) the IVF procedure compared with those patients in whom no bacteria were detected (32%). Those patients with semen cultures positive for Escherichia coli prior to the IVF procedure, but which cleared after treatment had a higher pregnancy rate (60%) compared with those patients who were positive for E.coli at the time of the attempt. The group of patients with Staphylococcus aureus in the semen at the time of IVF also demonstrated a low pregnancy rate (17%). Of the patients, 36 (11%) had positive Ureaplasma cultures from the screening test carried out on the semen and 22% became pregnant after successful treatment. None of the three patients with persistently positive cultures became pregnant. In conclusion, the presence of Enterococcus in semen does not affect pregnancy rates following IVF. E.coli, S.aureus and Ureaplasma urealyticum may have a negative effect and should be treated.

Original languageEnglish (US)
Pages (from-to)2789-2792
Number of pages4
JournalHuman Reproduction
Volume11
Issue number12
DOIs
StatePublished - Dec 1996
Externally publishedYes

Keywords

  • Bacterial infection
  • Enterococcus
  • In-vitro fertilization
  • Pregnancy rates
  • Semen

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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