TY - JOUR
T1 - The effect of physical activity across the menstrual cycle on reproductive function
AU - Ahrens, Katherine A.
AU - Vladutiu, Catherine J.
AU - Mumford, Sunni L.
AU - Schliep, Karen C.
AU - Perkins, Neil J.
AU - Wactawski-Wende, Jean
AU - Schisterman, Enrique F.
N1 - Funding Information:
Funding: This study was supported by the Intramural Research Program of the Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health (contract # HHSN275200403394C ). CV received financial support from grant T32-HL007055 from the National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland.
PY - 2014/2
Y1 - 2014/2
N2 - Purpose: To evaluate the association between physical activity (PA) across the menstrual cycle and reproductive function. Methods: The BioCycle Study (2005-2007) followed 259 healthy premenopausal women not using hormonal contraceptives for up to two menstrual cycles (N = 509 cycles). Serum leptin, estradiol, progesterone, luteinizing hormone, follicle-stimulating hormone, and testosterone were measured five to eight times per cycle. Linear mixed models were used to estimate the effect of past-week PA (measured four times during each cycle) on hormone levels. Past-week PA was categorized into tertiles based on metabolic equivalent of task hours per week (cut-points were 15.3 and 35.7). Risk ratios for sporadic anovulation were estimated using generalized linear models. Analyses adjusted for habitual PA (assessed at baseline), body mass index, race, age, and perceived stress. Linear mixed models used inverse probability weights to control for concurrent reproductive hormones and caloric intake. Results: High past-week PA was inversely associated with leptin (-6.6%; 95% confidence interval, -10.6 to -2.5) and luteal phase progesterone (-22.1%; -36.2 to -4.7) as compared with low past-week PA. High past-week PA was not significantly associated with sporadic anovulation (adjusted risk ratio, 1.5; 0.6 to 3.4). Conclusions: High levels of PA were modestly associated with changes in select hormones but not sporadic anovulation among moderate to highly active premenopausal women.
AB - Purpose: To evaluate the association between physical activity (PA) across the menstrual cycle and reproductive function. Methods: The BioCycle Study (2005-2007) followed 259 healthy premenopausal women not using hormonal contraceptives for up to two menstrual cycles (N = 509 cycles). Serum leptin, estradiol, progesterone, luteinizing hormone, follicle-stimulating hormone, and testosterone were measured five to eight times per cycle. Linear mixed models were used to estimate the effect of past-week PA (measured four times during each cycle) on hormone levels. Past-week PA was categorized into tertiles based on metabolic equivalent of task hours per week (cut-points were 15.3 and 35.7). Risk ratios for sporadic anovulation were estimated using generalized linear models. Analyses adjusted for habitual PA (assessed at baseline), body mass index, race, age, and perceived stress. Linear mixed models used inverse probability weights to control for concurrent reproductive hormones and caloric intake. Results: High past-week PA was inversely associated with leptin (-6.6%; 95% confidence interval, -10.6 to -2.5) and luteal phase progesterone (-22.1%; -36.2 to -4.7) as compared with low past-week PA. High past-week PA was not significantly associated with sporadic anovulation (adjusted risk ratio, 1.5; 0.6 to 3.4). Conclusions: High levels of PA were modestly associated with changes in select hormones but not sporadic anovulation among moderate to highly active premenopausal women.
KW - Hormones
KW - Leisure activity
KW - Menstrual cycle
KW - Motor activity
KW - Women
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U2 - 10.1016/j.annepidem.2013.11.002
DO - 10.1016/j.annepidem.2013.11.002
M3 - Article
C2 - 24345590
AN - SCOPUS:84892981539
SN - 1047-2797
VL - 24
SP - 127
EP - 134
JO - Annals of epidemiology
JF - Annals of epidemiology
IS - 2
ER -