The effect of pancreatic polypeptide on glucose disposal after surgical alterations of the pancreas

H. M. Prillaman, S. B. Cox, A. E. Freedlender, G. E. Cornett, H. A. Jones, T. L. Flanagan, R. E. Chance, J. A. Hoffmann, D. K. Andersen, D. Elahi, J. B. Hanks

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Surgical alterations of the pancreas result in anatomic changes that can affect postoperative glucose metabolism. Pancreas transplantation results in reduction of beta-cell mass, systemic release of insulin, and denervation. The authors hypothesized that such alterations affect peripheral glucose disposal to induce an 'insensitivity' to endogenously (systemically) released insulin. Additionally, they hypothesized that surgically induced deficiency of the postprandial hormone, pancreatic polypeptide, might contribute to altered glucose disposal. The authors studied two surgical models in dogs known to be devoid of pancreatic polypeptide-70% proximal pancreatectomy (PPx) and PPx plus distal pancreas autotransplantation (PAT/B). Oral glucose challenge and euglycemic hyperinsulinemic clamp studies were performed before and after a 16-day 'pulsed' infusion of pancreatic polypeptide. Both surgical procedures resulted in elevations in the integrated glucose response after oral glucose, which was not affected by pancreatic polypeptide infusion. Euglycemic clamp studies showed decreased hepatic glucose output (R(a)) and overall glucose disposal (R(d)) in the fasted state for both surgical groups. The transplant animals demonstrated significant decreases in R(d) during the hyperinsulinemic challenge (3.2 ± 0.01 versus 5.7 ± 0.01 mg/kg/minute at 60 to 120 minutes for PAT/B versus control). After 16 days of pancreatic polypeptide infusion, however, basal R(a), as well as basal and 60- to 120- minute R(d) values, were returned to control values in the transplant group. The authors conclude that pancreas transplantation results in altered glucose disposal, possibly due to an altered effectiveness of systemically released insulin. They conclude that pancreatic polypeptide is an important modulator of peripheral insulin action. Therefore, the role of pancreatic polypeptide must be taken into account when evaluating postoperative glucose metabolism in canine models of pancreas transplantation.

Original languageEnglish (US)
Pages (from-to)574-582
Number of pages9
JournalAnnals of surgery
Issue number5
StatePublished - 1992

ASJC Scopus subject areas

  • Surgery


Dive into the research topics of 'The effect of pancreatic polypeptide on glucose disposal after surgical alterations of the pancreas'. Together they form a unique fingerprint.

Cite this