The effect of paclitaxel powder on glaucoma filtration surgery in rabbits

Henry D Jampel, Jung Il Moon

Research output: Contribution to journalArticle

Abstract

Objective: The authors determine if the intraoperative placement of paclitaxel powder in the subconjunctival space improves the outcome of glaucoma filtration surgery in rabbits. Methods: A posterior lip sclerectomy was performed in the right eye of 24 New Zealand white rabbits. Before the conjunctiva was fully sutured, 8 mg of mannitol powder alone, or 8 mg of mannitol powder containing either 10 μg or 250 μg of paclitaxel, was placed in the subconjunctival space of six eyes each in masked fashion. An additional six animals were treated with episcleral application of a sponge soaked in a solution of 0.5 mg/ml of mitomycin C (MMC) for 5 minutes before the sclerectomy was performed. Intraocular pressure and bleb size were measured until the operation had failed or until the 7 weeks of observation had concluded. Results: Both paclitaxel powder and MMC solution improved the outcome of filtration surgery in this model as measured by magnitude of intraocular pressure (IOP) lowering and duration of surgical success. No toxic effect of either drug was observed, although endophthalmitis was observed in eight animals followed for more than 3 weeks. Conclusion: The introduction of paclitaxel into the subconjunctival space at the conclusion of filtration surgery has an effect comparable to intraoperative MMC.

Original languageEnglish (US)
Pages (from-to)170-177
Number of pages8
JournalJournal of Glaucoma
Volume7
Issue number3
StatePublished - Jun 1998

Fingerprint

Filtering Surgery
Paclitaxel
Glaucoma
Powders
Mitomycin
Rabbits
Mannitol
Intraocular Pressure
Endophthalmitis
Poisons
Conjunctiva
Porifera
Blister
Lip
Observation
Pharmaceutical Preparations

Keywords

  • Filtration surgery
  • Glaucoma
  • Mitomycin C
  • Paclitaxel powder
  • Rabbits

ASJC Scopus subject areas

  • Ophthalmology

Cite this

The effect of paclitaxel powder on glaucoma filtration surgery in rabbits. / Jampel, Henry D; Moon, Jung Il.

In: Journal of Glaucoma, Vol. 7, No. 3, 06.1998, p. 170-177.

Research output: Contribution to journalArticle

@article{5260a043b0b6462eaf5e969a01e59380,
title = "The effect of paclitaxel powder on glaucoma filtration surgery in rabbits",
abstract = "Objective: The authors determine if the intraoperative placement of paclitaxel powder in the subconjunctival space improves the outcome of glaucoma filtration surgery in rabbits. Methods: A posterior lip sclerectomy was performed in the right eye of 24 New Zealand white rabbits. Before the conjunctiva was fully sutured, 8 mg of mannitol powder alone, or 8 mg of mannitol powder containing either 10 μg or 250 μg of paclitaxel, was placed in the subconjunctival space of six eyes each in masked fashion. An additional six animals were treated with episcleral application of a sponge soaked in a solution of 0.5 mg/ml of mitomycin C (MMC) for 5 minutes before the sclerectomy was performed. Intraocular pressure and bleb size were measured until the operation had failed or until the 7 weeks of observation had concluded. Results: Both paclitaxel powder and MMC solution improved the outcome of filtration surgery in this model as measured by magnitude of intraocular pressure (IOP) lowering and duration of surgical success. No toxic effect of either drug was observed, although endophthalmitis was observed in eight animals followed for more than 3 weeks. Conclusion: The introduction of paclitaxel into the subconjunctival space at the conclusion of filtration surgery has an effect comparable to intraoperative MMC.",
keywords = "Filtration surgery, Glaucoma, Mitomycin C, Paclitaxel powder, Rabbits",
author = "Jampel, {Henry D} and Moon, {Jung Il}",
year = "1998",
month = "6",
language = "English (US)",
volume = "7",
pages = "170--177",
journal = "Journal of Glaucoma",
issn = "1057-0829",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

TY - JOUR

T1 - The effect of paclitaxel powder on glaucoma filtration surgery in rabbits

AU - Jampel, Henry D

AU - Moon, Jung Il

PY - 1998/6

Y1 - 1998/6

N2 - Objective: The authors determine if the intraoperative placement of paclitaxel powder in the subconjunctival space improves the outcome of glaucoma filtration surgery in rabbits. Methods: A posterior lip sclerectomy was performed in the right eye of 24 New Zealand white rabbits. Before the conjunctiva was fully sutured, 8 mg of mannitol powder alone, or 8 mg of mannitol powder containing either 10 μg or 250 μg of paclitaxel, was placed in the subconjunctival space of six eyes each in masked fashion. An additional six animals were treated with episcleral application of a sponge soaked in a solution of 0.5 mg/ml of mitomycin C (MMC) for 5 minutes before the sclerectomy was performed. Intraocular pressure and bleb size were measured until the operation had failed or until the 7 weeks of observation had concluded. Results: Both paclitaxel powder and MMC solution improved the outcome of filtration surgery in this model as measured by magnitude of intraocular pressure (IOP) lowering and duration of surgical success. No toxic effect of either drug was observed, although endophthalmitis was observed in eight animals followed for more than 3 weeks. Conclusion: The introduction of paclitaxel into the subconjunctival space at the conclusion of filtration surgery has an effect comparable to intraoperative MMC.

AB - Objective: The authors determine if the intraoperative placement of paclitaxel powder in the subconjunctival space improves the outcome of glaucoma filtration surgery in rabbits. Methods: A posterior lip sclerectomy was performed in the right eye of 24 New Zealand white rabbits. Before the conjunctiva was fully sutured, 8 mg of mannitol powder alone, or 8 mg of mannitol powder containing either 10 μg or 250 μg of paclitaxel, was placed in the subconjunctival space of six eyes each in masked fashion. An additional six animals were treated with episcleral application of a sponge soaked in a solution of 0.5 mg/ml of mitomycin C (MMC) for 5 minutes before the sclerectomy was performed. Intraocular pressure and bleb size were measured until the operation had failed or until the 7 weeks of observation had concluded. Results: Both paclitaxel powder and MMC solution improved the outcome of filtration surgery in this model as measured by magnitude of intraocular pressure (IOP) lowering and duration of surgical success. No toxic effect of either drug was observed, although endophthalmitis was observed in eight animals followed for more than 3 weeks. Conclusion: The introduction of paclitaxel into the subconjunctival space at the conclusion of filtration surgery has an effect comparable to intraoperative MMC.

KW - Filtration surgery

KW - Glaucoma

KW - Mitomycin C

KW - Paclitaxel powder

KW - Rabbits

UR - http://www.scopus.com/inward/record.url?scp=0031838071&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031838071&partnerID=8YFLogxK

M3 - Article

C2 - 9627856

AN - SCOPUS:0031838071

VL - 7

SP - 170

EP - 177

JO - Journal of Glaucoma

JF - Journal of Glaucoma

SN - 1057-0829

IS - 3

ER -