The effect of paclitaxel powder on glaucoma filtration surgery in rabbits

Henry D. Jampel, Jung Il Moon

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: The authors determine if the intraoperative placement of paclitaxel powder in the subconjunctival space improves the outcome of glaucoma filtration surgery in rabbits. Methods: A posterior lip sclerectomy was performed in the right eye of 24 New Zealand white rabbits. Before the conjunctiva was fully sutured, 8 mg of mannitol powder alone, or 8 mg of mannitol powder containing either 10 μg or 250 μg of paclitaxel, was placed in the subconjunctival space of six eyes each in masked fashion. An additional six animals were treated with episcleral application of a sponge soaked in a solution of 0.5 mg/ml of mitomycin C (MMC) for 5 minutes before the sclerectomy was performed. Intraocular pressure and bleb size were measured until the operation had failed or until the 7 weeks of observation had concluded. Results: Both paclitaxel powder and MMC solution improved the outcome of filtration surgery in this model as measured by magnitude of intraocular pressure (IOP) lowering and duration of surgical success. No toxic effect of either drug was observed, although endophthalmitis was observed in eight animals followed for more than 3 weeks. Conclusion: The introduction of paclitaxel into the subconjunctival space at the conclusion of filtration surgery has an effect comparable to intraoperative MMC.

Original languageEnglish (US)
Pages (from-to)170-177
Number of pages8
JournalJournal of glaucoma
Volume7
Issue number3
DOIs
StatePublished - Jun 1998

Keywords

  • Filtration surgery
  • Glaucoma
  • Mitomycin C
  • Paclitaxel powder
  • Rabbits

ASJC Scopus subject areas

  • Ophthalmology

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