The effect of oral phosphate administration on major indices of skeletal metabolism in normal subjects.

S. J. Silverberg, E. Shane, Thomas Clemens, D. W. Dempster, G. V. Segre, R. Lindsay, J. P. Bilezikian

Research output: Contribution to journalArticle

Abstract

The effect of brief periods of phosphate administration on indices of human skeletal metabolism was investigated. Thirteen subjects (8 women, 5 men; 19-36 years old) received 2 g of oral phosphate daily for 5 days. Serum phosphorus rose 26% (3.8 +/- 0.1 mg/dl to 4.8 +/- 0.1 mg/dl; p less than .01) while total calcium fell (9.3 +/- 0.1 mg/dl to 8.9 +/- 0.1 mg/dl; p less than .01). Parathyroid hormone levels increased by 50% (14.1 +/- 2.0 pg/ml to 21.5 +/- 1.7 pg/ml; p less than .05) although values remained within the normal range. A persistent phosphaturia (0.64 +/- 0.10 g/g Cr to 1.8 +/- 0.4 g/g Cr; p less than .05) and a 69% fall in urinary calcium (80.8 +/- 10.0 mg/g Cr to 24.6 +/- 6.0 mg/g Cr; p less than .001) were observed. 1,25-dihydroxyvitamin D3 and urinary hydroxyproline concentrations did not change significantly but the bone gamma-carboxyglutamic acid protein (BGP) concentration rose 41% by day 2 (9.6 +/- 1.3 mg/ml to 13.5 +/- 2.2 mg/ml; p less than .005) and remained elevated throughout the study period. These results support the possibility that brief periods of phosphate administration may be useful in the therapy of disorders associated with low bone turnover, such as osteoporosis.

Original languageEnglish (US)
Pages (from-to)383-388
Number of pages6
JournalJournal of Bone and Mineral Research
Volume1
Issue number4
StatePublished - Aug 1986
Externally publishedYes

Fingerprint

Oral Administration
Phosphates
Familial Hypophosphatemia
Calcium
Calcitriol
Bone Remodeling
Hydroxyproline
Osteocalcin
Parathyroid Hormone
Phosphorus
Osteoporosis
Reference Values
Serum
Therapeutics

ASJC Scopus subject areas

  • Surgery

Cite this

Silverberg, S. J., Shane, E., Clemens, T., Dempster, D. W., Segre, G. V., Lindsay, R., & Bilezikian, J. P. (1986). The effect of oral phosphate administration on major indices of skeletal metabolism in normal subjects. Journal of Bone and Mineral Research, 1(4), 383-388.

The effect of oral phosphate administration on major indices of skeletal metabolism in normal subjects. / Silverberg, S. J.; Shane, E.; Clemens, Thomas; Dempster, D. W.; Segre, G. V.; Lindsay, R.; Bilezikian, J. P.

In: Journal of Bone and Mineral Research, Vol. 1, No. 4, 08.1986, p. 383-388.

Research output: Contribution to journalArticle

Silverberg, SJ, Shane, E, Clemens, T, Dempster, DW, Segre, GV, Lindsay, R & Bilezikian, JP 1986, 'The effect of oral phosphate administration on major indices of skeletal metabolism in normal subjects.', Journal of Bone and Mineral Research, vol. 1, no. 4, pp. 383-388.
Silverberg, S. J. ; Shane, E. ; Clemens, Thomas ; Dempster, D. W. ; Segre, G. V. ; Lindsay, R. ; Bilezikian, J. P. / The effect of oral phosphate administration on major indices of skeletal metabolism in normal subjects. In: Journal of Bone and Mineral Research. 1986 ; Vol. 1, No. 4. pp. 383-388.
@article{edf8a6da1c0f43bd870ea79c2461e3c4,
title = "The effect of oral phosphate administration on major indices of skeletal metabolism in normal subjects.",
abstract = "The effect of brief periods of phosphate administration on indices of human skeletal metabolism was investigated. Thirteen subjects (8 women, 5 men; 19-36 years old) received 2 g of oral phosphate daily for 5 days. Serum phosphorus rose 26{\%} (3.8 +/- 0.1 mg/dl to 4.8 +/- 0.1 mg/dl; p less than .01) while total calcium fell (9.3 +/- 0.1 mg/dl to 8.9 +/- 0.1 mg/dl; p less than .01). Parathyroid hormone levels increased by 50{\%} (14.1 +/- 2.0 pg/ml to 21.5 +/- 1.7 pg/ml; p less than .05) although values remained within the normal range. A persistent phosphaturia (0.64 +/- 0.10 g/g Cr to 1.8 +/- 0.4 g/g Cr; p less than .05) and a 69{\%} fall in urinary calcium (80.8 +/- 10.0 mg/g Cr to 24.6 +/- 6.0 mg/g Cr; p less than .001) were observed. 1,25-dihydroxyvitamin D3 and urinary hydroxyproline concentrations did not change significantly but the bone gamma-carboxyglutamic acid protein (BGP) concentration rose 41{\%} by day 2 (9.6 +/- 1.3 mg/ml to 13.5 +/- 2.2 mg/ml; p less than .005) and remained elevated throughout the study period. These results support the possibility that brief periods of phosphate administration may be useful in the therapy of disorders associated with low bone turnover, such as osteoporosis.",
author = "Silverberg, {S. J.} and E. Shane and Thomas Clemens and Dempster, {D. W.} and Segre, {G. V.} and R. Lindsay and Bilezikian, {J. P.}",
year = "1986",
month = "8",
language = "English (US)",
volume = "1",
pages = "383--388",
journal = "Journal of Bone and Mineral Research",
issn = "0884-0431",
publisher = "Wiley-Blackwell",
number = "4",

}

TY - JOUR

T1 - The effect of oral phosphate administration on major indices of skeletal metabolism in normal subjects.

AU - Silverberg, S. J.

AU - Shane, E.

AU - Clemens, Thomas

AU - Dempster, D. W.

AU - Segre, G. V.

AU - Lindsay, R.

AU - Bilezikian, J. P.

PY - 1986/8

Y1 - 1986/8

N2 - The effect of brief periods of phosphate administration on indices of human skeletal metabolism was investigated. Thirteen subjects (8 women, 5 men; 19-36 years old) received 2 g of oral phosphate daily for 5 days. Serum phosphorus rose 26% (3.8 +/- 0.1 mg/dl to 4.8 +/- 0.1 mg/dl; p less than .01) while total calcium fell (9.3 +/- 0.1 mg/dl to 8.9 +/- 0.1 mg/dl; p less than .01). Parathyroid hormone levels increased by 50% (14.1 +/- 2.0 pg/ml to 21.5 +/- 1.7 pg/ml; p less than .05) although values remained within the normal range. A persistent phosphaturia (0.64 +/- 0.10 g/g Cr to 1.8 +/- 0.4 g/g Cr; p less than .05) and a 69% fall in urinary calcium (80.8 +/- 10.0 mg/g Cr to 24.6 +/- 6.0 mg/g Cr; p less than .001) were observed. 1,25-dihydroxyvitamin D3 and urinary hydroxyproline concentrations did not change significantly but the bone gamma-carboxyglutamic acid protein (BGP) concentration rose 41% by day 2 (9.6 +/- 1.3 mg/ml to 13.5 +/- 2.2 mg/ml; p less than .005) and remained elevated throughout the study period. These results support the possibility that brief periods of phosphate administration may be useful in the therapy of disorders associated with low bone turnover, such as osteoporosis.

AB - The effect of brief periods of phosphate administration on indices of human skeletal metabolism was investigated. Thirteen subjects (8 women, 5 men; 19-36 years old) received 2 g of oral phosphate daily for 5 days. Serum phosphorus rose 26% (3.8 +/- 0.1 mg/dl to 4.8 +/- 0.1 mg/dl; p less than .01) while total calcium fell (9.3 +/- 0.1 mg/dl to 8.9 +/- 0.1 mg/dl; p less than .01). Parathyroid hormone levels increased by 50% (14.1 +/- 2.0 pg/ml to 21.5 +/- 1.7 pg/ml; p less than .05) although values remained within the normal range. A persistent phosphaturia (0.64 +/- 0.10 g/g Cr to 1.8 +/- 0.4 g/g Cr; p less than .05) and a 69% fall in urinary calcium (80.8 +/- 10.0 mg/g Cr to 24.6 +/- 6.0 mg/g Cr; p less than .001) were observed. 1,25-dihydroxyvitamin D3 and urinary hydroxyproline concentrations did not change significantly but the bone gamma-carboxyglutamic acid protein (BGP) concentration rose 41% by day 2 (9.6 +/- 1.3 mg/ml to 13.5 +/- 2.2 mg/ml; p less than .005) and remained elevated throughout the study period. These results support the possibility that brief periods of phosphate administration may be useful in the therapy of disorders associated with low bone turnover, such as osteoporosis.

UR - http://www.scopus.com/inward/record.url?scp=0022758152&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022758152&partnerID=8YFLogxK

M3 - Article

VL - 1

SP - 383

EP - 388

JO - Journal of Bone and Mineral Research

JF - Journal of Bone and Mineral Research

SN - 0884-0431

IS - 4

ER -