The effect of oral phosphate administration on major indices of skeletal metabolism in normal subjects

Shonni J. Silverberg, Elizabeth Shane, Thomas L. Clemens, David W. Dempster, Gino V. Segre, Robert Lindsay, John P. Bilezikian

Research output: Contribution to journalArticle

Abstract

The effect of brief periods of phosphate administration on indices of human skeletal metabolism was investigated. Thirteen subjects (8 women, 5 men; 19–36 years old) received 2 g of oral phosphate daily for 5 days. Serum phosphorus rose 26% (3.8 ± 0.1 mg/dl to 4.8 ± 0.1 mg/dl; p < .01) while total calcium fell (9.3 ± 0.1 mg/dl to 8.9 ± 0.1 mg/dl; p < .01). Parathyroid hormone levels increased by 50% (14.1 ± 2.0 pg/ml to 21.5 ± 1.7 pg/ml; p < .05) although values remained within the normal range. A persistent phosphaturia (0.64 ± 0.10 g/g Cr to 1.8 ± 0.4 g/g Cr; p < .05) and a 69% fall in urinary calcium (80.8 ± 10.0 mg/g Cr to 24.6 ± 6.0 mg/g Cr; p < .001) were observed. 1,25‐dihydroxyvitamin D3 and urinary hydroxyproline concentrations did not change significantly but the bone γ‐carboxyglutamic acid protein (BGP) concentration rose 41% by day 2 (9.6 ± 1.3 mg/ml to 13.5 ± 2.2 mg/ml; p < .005) and remained elevated throughout the study period. These results support the possibility that brief periods of phosphate administration may be useful in the therapy of disorders associated with low bone turnover, such as osteoporosis.

Original languageEnglish (US)
Pages (from-to)383-388
Number of pages6
JournalJournal of Bone and Mineral Research
Volume1
Issue number4
DOIs
StatePublished - Aug 1986
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Orthopedics and Sports Medicine

Fingerprint Dive into the research topics of 'The effect of oral phosphate administration on major indices of skeletal metabolism in normal subjects'. Together they form a unique fingerprint.

Cite this