—Dorsal root ganglia from 8‐day‐ and 14‐day‐old chick embryos contained gangliosides with a pattern qualitatively similar to that of embryonic chick brain. The pattern of gangliosides from dorsal root ganglia changed with age, there being a decrease in polysialogangliosides with increasing age. When isolated, dorsal root ganglia were incubated in the presence of a concentration of nerve growth factor (NGF) sufficient to promote the outgrowth of nerve fibres, there was increased incorporation of d‐[1‐14C]glucosamine into gangliosides. There was, however, no difference in the pattern of incorporation into gangliosides by control ganglia and those exposed to NGF.
|Original language||English (US)|
|Number of pages||9|
|Journal||Journal of Neurochemistry|
|State||Published - Nov 1969|
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience