THE EFFECT OF NERVE GROWTH FACTOR (NGF) ON THE SYNTHESIS OF GANGLIOSIDES

M. Graves, S. Varon, G. McKhann

Research output: Contribution to journalArticlepeer-review

Abstract

—Dorsal root ganglia from 8‐day‐ and 14‐day‐old chick embryos contained gangliosides with a pattern qualitatively similar to that of embryonic chick brain. The pattern of gangliosides from dorsal root ganglia changed with age, there being a decrease in polysialogangliosides with increasing age. When isolated, dorsal root ganglia were incubated in the presence of a concentration of nerve growth factor (NGF) sufficient to promote the outgrowth of nerve fibres, there was increased incorporation of d‐[1‐14C]glucosamine into gangliosides. There was, however, no difference in the pattern of incorporation into gangliosides by control ganglia and those exposed to NGF.

Original languageEnglish (US)
Pages (from-to)1533-1541
Number of pages9
JournalJournal of Neurochemistry
Volume16
Issue number11
DOIs
StatePublished - Nov 1969

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

Fingerprint Dive into the research topics of 'THE EFFECT OF NERVE GROWTH FACTOR (NGF) ON THE SYNTHESIS OF GANGLIOSIDES'. Together they form a unique fingerprint.

Cite this