TY - JOUR
T1 - THE EFFECT OF NERVE GROWTH FACTOR (NGF) ON THE SYNTHESIS OF GANGLIOSIDES
AU - Graves, M.
AU - Varon, S.
AU - McKhann, G.
PY - 1969/11
Y1 - 1969/11
N2 - —Dorsal root ganglia from 8‐day‐ and 14‐day‐old chick embryos contained gangliosides with a pattern qualitatively similar to that of embryonic chick brain. The pattern of gangliosides from dorsal root ganglia changed with age, there being a decrease in polysialogangliosides with increasing age. When isolated, dorsal root ganglia were incubated in the presence of a concentration of nerve growth factor (NGF) sufficient to promote the outgrowth of nerve fibres, there was increased incorporation of d‐[1‐14C]glucosamine into gangliosides. There was, however, no difference in the pattern of incorporation into gangliosides by control ganglia and those exposed to NGF.
AB - —Dorsal root ganglia from 8‐day‐ and 14‐day‐old chick embryos contained gangliosides with a pattern qualitatively similar to that of embryonic chick brain. The pattern of gangliosides from dorsal root ganglia changed with age, there being a decrease in polysialogangliosides with increasing age. When isolated, dorsal root ganglia were incubated in the presence of a concentration of nerve growth factor (NGF) sufficient to promote the outgrowth of nerve fibres, there was increased incorporation of d‐[1‐14C]glucosamine into gangliosides. There was, however, no difference in the pattern of incorporation into gangliosides by control ganglia and those exposed to NGF.
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U2 - 10.1111/j.1471-4159.1969.tb09909.x
DO - 10.1111/j.1471-4159.1969.tb09909.x
M3 - Article
C2 - 5380013
AN - SCOPUS:0014598801
SN - 0022-3042
VL - 16
SP - 1533
EP - 1541
JO - Journal of Neurochemistry
JF - Journal of Neurochemistry
IS - 11
ER -