The Effect of Neodymium:YAG Laser Capsulotomy on Aqueous Humor Dynamics in the Monkey Eye

Mary G. Lynch; Harry A. Quigley; W. Richard Green; Irvin P. Pollack; Alan L. Robin

doi:10.1016/S0161-6420(86)33575-9

The Effect of Neodymium:YAG Laser Capsulotomy on Aqueous Humor Dynamics in the Monkey Eye

Mary G. Lynch, Harry A. Quigley, W. Richard Green, Irvin P. Pollack, Alan L. Robin

School of Medicine

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

The creation of a posterior capsulotomy utilizing a neodymium:YAG (Nd:YAG) laser is often followed by an increase in the intraocular pressure (IOP). In order to study the cause of this pressure rise, six eyes of three cynomolgus monkeys underwent extacapsular cataract extraction followed 2 to 3 months later by Nd:YAG laser capsulotomy. Eyes were evaluated clinically and examined histopathologically at 1 hour, 3 hours, 1 day, 3 days, 1 week, and 1 month after laser treatment. Although IOP did not increase after laser capsulotomy, outflow facility was decreased 80% from baseline levels at 3 hours, 1 day, and 3 days. After laser treatment, the anterior chamber and meshwork contained fibrin, lens material, inflammatory cells, pigmented macrophages, erythrocytes, and free pigment. Most of these elements had cleared the meshwork by 1 month.

Original language	English (US)
Pages (from-to)	1270-1275
Number of pages	6
Journal	Ophthalmology
Volume	93
Issue number	10
DOIs	https://doi.org/10.1016/S0161-6420(86)33575-9
State	Published - 1986

Keywords

Nd:YAG laser
aqueous humor dynamics
capsulotomy
primate

ASJC Scopus subject areas

Ophthalmology

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10.1016/S0161-6420(86)33575-9

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@article{b9a1847c406a425394efe05971857298,

title = "The Effect of Neodymium:YAG Laser Capsulotomy on Aqueous Humor Dynamics in the Monkey Eye",

abstract = "The creation of a posterior capsulotomy utilizing a neodymium:YAG (Nd:YAG) laser is often followed by an increase in the intraocular pressure (IOP). In order to study the cause of this pressure rise, six eyes of three cynomolgus monkeys underwent extacapsular cataract extraction followed 2 to 3 months later by Nd:YAG laser capsulotomy. Eyes were evaluated clinically and examined histopathologically at 1 hour, 3 hours, 1 day, 3 days, 1 week, and 1 month after laser treatment. Although IOP did not increase after laser capsulotomy, outflow facility was decreased 80% from baseline levels at 3 hours, 1 day, and 3 days. After laser treatment, the anterior chamber and meshwork contained fibrin, lens material, inflammatory cells, pigmented macrophages, erythrocytes, and free pigment. Most of these elements had cleared the meshwork by 1 month.",

keywords = "Nd:YAG laser, aqueous humor dynamics, capsulotomy, primate",

author = "Lynch, {Mary G.} and Quigley, {Harry A.} and Green, {W. Richard} and Pollack, {Irvin P.} and Robin, {Alan L.}",

note = "Funding Information: Supported in part by PHS Research Grants EY 02120 (Dr. Quigley) and EY 01765 (Core Grant, Wilmer Institute), both awarded by the National Eye Institute, National Institutes of Health, Bethesda, Maryland, and by a grant from the American Health Assistance Foundation (Dr. Quigley). Copyright: Copyright 2017 Elsevier B.V., All rights reserved.",

year = "1986",

doi = "10.1016/S0161-6420(86)33575-9",

language = "English (US)",

volume = "93",

pages = "1270--1275",

journal = "Ophthalmology",

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AU - Lynch, Mary G.

AU - Quigley, Harry A.

AU - Green, W. Richard

AU - Pollack, Irvin P.

AU - Robin, Alan L.

N1 - Funding Information: Supported in part by PHS Research Grants EY 02120 (Dr. Quigley) and EY 01765 (Core Grant, Wilmer Institute), both awarded by the National Eye Institute, National Institutes of Health, Bethesda, Maryland, and by a grant from the American Health Assistance Foundation (Dr. Quigley). Copyright: Copyright 2017 Elsevier B.V., All rights reserved.

PY - 1986

Y1 - 1986

N2 - The creation of a posterior capsulotomy utilizing a neodymium:YAG (Nd:YAG) laser is often followed by an increase in the intraocular pressure (IOP). In order to study the cause of this pressure rise, six eyes of three cynomolgus monkeys underwent extacapsular cataract extraction followed 2 to 3 months later by Nd:YAG laser capsulotomy. Eyes were evaluated clinically and examined histopathologically at 1 hour, 3 hours, 1 day, 3 days, 1 week, and 1 month after laser treatment. Although IOP did not increase after laser capsulotomy, outflow facility was decreased 80% from baseline levels at 3 hours, 1 day, and 3 days. After laser treatment, the anterior chamber and meshwork contained fibrin, lens material, inflammatory cells, pigmented macrophages, erythrocytes, and free pigment. Most of these elements had cleared the meshwork by 1 month.

AB - The creation of a posterior capsulotomy utilizing a neodymium:YAG (Nd:YAG) laser is often followed by an increase in the intraocular pressure (IOP). In order to study the cause of this pressure rise, six eyes of three cynomolgus monkeys underwent extacapsular cataract extraction followed 2 to 3 months later by Nd:YAG laser capsulotomy. Eyes were evaluated clinically and examined histopathologically at 1 hour, 3 hours, 1 day, 3 days, 1 week, and 1 month after laser treatment. Although IOP did not increase after laser capsulotomy, outflow facility was decreased 80% from baseline levels at 3 hours, 1 day, and 3 days. After laser treatment, the anterior chamber and meshwork contained fibrin, lens material, inflammatory cells, pigmented macrophages, erythrocytes, and free pigment. Most of these elements had cleared the meshwork by 1 month.

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KW - aqueous humor dynamics

KW - capsulotomy

KW - primate

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The Effect of Neodymium:YAG Laser Capsulotomy on Aqueous Humor Dynamics in the Monkey Eye

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Keywords

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