TY - JOUR
T1 - The effect of nandrolone decanoate on bone mineral density, muscle mass, and hemoglobin levels in elderly women with osteoporosis
T2 - A double-blind, randomized, placebo-controlled clinical trial
AU - Frisoli, Alberto
AU - Chaves, Paulo H.M.
AU - Pinheiro, Marcelo Medeiros
AU - Szejnfeld, Vera Lucia
N1 - Funding Information:
This work was partially supported by contract 99/06492-3 from the Fundac¸ão de Apoio a Pesquisa do Estado de São Paulo (FAPESP).
PY - 2005/5
Y1 - 2005/5
N2 - Methods. In a randomized, double-blind, placebo-controlled clinical trial, we evaluated the effect of a 2-year treatment with nandrolone decanoate (ND) on bone mineral density (BMD) of lumbar spine, femoral neck, and trochanter and on vertebral fracture rate, muscle mass, and hemoglobin levels. Sixty-five osteoporotic women older than 70 years were studied. Thirty-two patients received injections of 50 mg ND. and 33 received placebos every 3 weeks. All patients received 500 mg calcium tablets daily. Results. Compared to baseline, ND increased the BMD of the lumbar spine (3.4% ± 6.0 and 3.7% ± 7.4; p < .05) and femoral neck (4.1% ± 7.3 and 4.7% ± 8.0; p < .05) after 1 and 2 years, respectively. The BMD of trochanter increased significantly only after the first year (4.8% ± 9.3, p < .05). Compared to the placebo group, the ND group presented with significantly increased BMD of the trochanter and neck. ND significantly reduced incidence of new vertebral fractures (21% vs 43% in the placebo group; p < .05). ND showed a significant statistical increase in lean body mass after the first (6.2% ± 5.8; p < .01) and second years (11.9% ± 29.2; p < .01). In addition, a 2-year treatment with ND significantly increased hemoglobin levels compared to baseline (14.3%; p < .01) and placebo (p < .01). Conclusions. ND increased BMD, hemoglobin levels, and muscle mass, and reduced the vertebral fracture rate of elderly osteoporotic women.
AB - Methods. In a randomized, double-blind, placebo-controlled clinical trial, we evaluated the effect of a 2-year treatment with nandrolone decanoate (ND) on bone mineral density (BMD) of lumbar spine, femoral neck, and trochanter and on vertebral fracture rate, muscle mass, and hemoglobin levels. Sixty-five osteoporotic women older than 70 years were studied. Thirty-two patients received injections of 50 mg ND. and 33 received placebos every 3 weeks. All patients received 500 mg calcium tablets daily. Results. Compared to baseline, ND increased the BMD of the lumbar spine (3.4% ± 6.0 and 3.7% ± 7.4; p < .05) and femoral neck (4.1% ± 7.3 and 4.7% ± 8.0; p < .05) after 1 and 2 years, respectively. The BMD of trochanter increased significantly only after the first year (4.8% ± 9.3, p < .05). Compared to the placebo group, the ND group presented with significantly increased BMD of the trochanter and neck. ND significantly reduced incidence of new vertebral fractures (21% vs 43% in the placebo group; p < .05). ND showed a significant statistical increase in lean body mass after the first (6.2% ± 5.8; p < .01) and second years (11.9% ± 29.2; p < .01). In addition, a 2-year treatment with ND significantly increased hemoglobin levels compared to baseline (14.3%; p < .01) and placebo (p < .01). Conclusions. ND increased BMD, hemoglobin levels, and muscle mass, and reduced the vertebral fracture rate of elderly osteoporotic women.
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U2 - 10.1093/gerona/60.5.648
DO - 10.1093/gerona/60.5.648
M3 - Article
C2 - 15972619
AN - SCOPUS:20744460348
SN - 1079-5006
VL - 60
SP - 648
EP - 653
JO - Journals of Gerontology - Series A Biological Sciences and Medical Sciences
JF - Journals of Gerontology - Series A Biological Sciences and Medical Sciences
IS - 5
ER -