The Effect of Multiple Rounds of Mass Drug Administration on the Association between Ocular Chlamydia trachomatis Infection and Follicular Trachoma in Preschool-Aged Children

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Abstract

Purpose:To examine the relationship between ocular Chlamydia trachomatis infection and follicular trachoma (TF) in children prior to and following multiple rounds of annual mass drug administration (MDA) with azithromycin.Methodology/principal findings:Thirty-two communities with endemic trachoma in Kongwa District, Tanzania, were offered annual MDA as part of a district-wide trachoma control program. Presence of ocular C. trachomatis infection and TF were assessed in 3,200 randomly sampled children aged five years and younger, who were examined prior to each MDA. Infection was detected using the Amplicor CT/NG assay and TF was identified by clinical examination using the World Health Organization (WHO) simplified grading system. The association between chlamydial infection and TF in children was evaluated at baseline prior to any treatment, and 12 months after each of three annual rounds of mass treatment. Factors associated with infection were examined using generalized estimating equation models.At baseline, the overall prevalence of chlamydial infection and TF was 22% and 31%, respectively. Among children with clinical signs of TF, the proportion of those with infection was 49% prior to treatment and declined to 30% after three MDAs. The odds of infection positivity among children with clinical signs of TF decreased by 26% (OR 0.74, 95% CI 0.65 to 0.84, p =

Original languageEnglish (US)
Article numbere2761
JournalPLoS Neglected Tropical Diseases
Volume8
Issue number4
DOIs
StatePublished - 2014

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Eye Infections
Trachoma
Chlamydia Infections
Chlamydia trachomatis
Preschool Children
Infection
Pharmaceutical Preparations
Azithromycin
Tanzania
Therapeutics

ASJC Scopus subject areas

  • Infectious Diseases
  • Public Health, Environmental and Occupational Health
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

@article{808bc7673bb8492a912c754eac733a60,
title = "The Effect of Multiple Rounds of Mass Drug Administration on the Association between Ocular Chlamydia trachomatis Infection and Follicular Trachoma in Preschool-Aged Children",
abstract = "Purpose:To examine the relationship between ocular Chlamydia trachomatis infection and follicular trachoma (TF) in children prior to and following multiple rounds of annual mass drug administration (MDA) with azithromycin.Methodology/principal findings:Thirty-two communities with endemic trachoma in Kongwa District, Tanzania, were offered annual MDA as part of a district-wide trachoma control program. Presence of ocular C. trachomatis infection and TF were assessed in 3,200 randomly sampled children aged five years and younger, who were examined prior to each MDA. Infection was detected using the Amplicor CT/NG assay and TF was identified by clinical examination using the World Health Organization (WHO) simplified grading system. The association between chlamydial infection and TF in children was evaluated at baseline prior to any treatment, and 12 months after each of three annual rounds of mass treatment. Factors associated with infection were examined using generalized estimating equation models.At baseline, the overall prevalence of chlamydial infection and TF was 22{\%} and 31{\%}, respectively. Among children with clinical signs of TF, the proportion of those with infection was 49{\%} prior to treatment and declined to 30{\%} after three MDAs. The odds of infection positivity among children with clinical signs of TF decreased by 26{\%} (OR 0.74, 95{\%} CI 0.65 to 0.84, p =",
author = "Jennifer Lee and Beatriz Munoz and Harran Mkocha and Gaydos, {Charlotte A} and Quinn, {Thomas C} and West, {Sheila K}",
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AU - West, Sheila K

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