The effect of morphine on glial cells as a potential therapeutic target for pharmacological development of analgesic drugs

Haroon Hameed, Mariam Hameed, Paul Christo

Research output: Contribution to journalArticle

Abstract

Opioids have played a critical role in achieving pain relief in both modern and ancient medicine. Yet, their clinical use can be limited secondary to unwanted side effects such as tolerance, dependence, reward, and behavioral changes. Identification of glial-mediated mechanisms inducing opioid side effects include cytokine receptors, ?-opioid receptors, N-methyl-D-aspartate receptors, and the recently elucidated Toll-like receptors. Newer agents targeting these receptors such as AV411, MK-801, AV333, and SLC022, and older agents used outside the United States or for other disease conditions, such as minocycline, pentoxifylline, and UV50488H, all show varied but promising profiles for providing significant relief from opioid side effects, while simultaneously potentiating opioid analgesia.

Original languageEnglish (US)
Pages (from-to)96-104
Number of pages9
JournalCurrent Pain and Headache Reports
Volume14
Issue number2
DOIs
StatePublished - Apr 2010

Fingerprint

Neuroglia
Morphine
Opioid Analgesics
Analgesics
Pharmacology
Pentoxifylline
Modern 1601-history
Minocycline
Cytokine Receptors
Dizocilpine Maleate
Toll-Like Receptors
Opioid Receptors
Therapeutics
N-Methyl-D-Aspartate Receptors
Reward
Analgesia
Pain

Keywords

  • Analgesia
  • Chronic pain
  • Dependence
  • Dizocilpine
  • Glial cell
  • Ibudilast
  • Minocycline
  • Morphine
  • NMDA
  • Opioid receptor
  • Pain relief
  • Pentoxifylline
  • Propentofylline
  • Reward
  • Tolerance
  • Toll-like receptor

ASJC Scopus subject areas

  • Clinical Neurology
  • Anesthesiology and Pain Medicine

Cite this

The effect of morphine on glial cells as a potential therapeutic target for pharmacological development of analgesic drugs. / Hameed, Haroon; Hameed, Mariam; Christo, Paul.

In: Current Pain and Headache Reports, Vol. 14, No. 2, 04.2010, p. 96-104.

Research output: Contribution to journalArticle

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