The effect of milrinone administrated before weaning from cardiopulmonary bypass in adult cardiac surgery

Narutoshi Hibino, T. Tomino, H. Satoh, M. Hamawaki, M. Imura, T. Suzuki, M. Inukai

Research output: Contribution to journalArticle

Abstract

We investigated the effect of milrinone (phoshphodiesterase III inhibitor) on postoperative hemodynamics in adult eighteen cardiac surgical patients (mean LVEF = 63%). Milrinone was administrated just after the aortic declamping during CPB. Comparing with control group, systemic vascular resistance decreased significantly and sufficient inotropic effect was sustained. In order to keep proper blood pressure much more cathechoramine dose was need when milrinone dose increased during this study. This is supposed that milrinone affected strong vasodilating effect and caused relative hypovolemic condition to the patient who showed good cardiac function. Milrinone causes best efficacy to the patient of poor cardiac function when he showed deconpensation or relatively hypervolemic hemodynamic condition.

Original languageEnglish (US)
Pages (from-to)1019-1023
Number of pages5
JournalKyobu geka. The Japanese journal of thoracic surgery
Volume53
Issue number12
StatePublished - 2000
Externally publishedYes

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    Hibino, N., Tomino, T., Satoh, H., Hamawaki, M., Imura, M., Suzuki, T., & Inukai, M. (2000). The effect of milrinone administrated before weaning from cardiopulmonary bypass in adult cardiac surgery. Kyobu geka. The Japanese journal of thoracic surgery, 53(12), 1019-1023.