The effect of metrizamide on regional brain glucose metabolism in the rat

Lars Bech, Nils Henrik Diemer, Albert Gjedde

Research output: Contribution to journalArticlepeer-review

Abstract

ABSTRACT— The X‐ray contrast material metrizamide is structurally related to 2‐deoxyglucose and inhibits brain glucose phosphorylation in vitro. In vivo, the present autoradiographic study with labeled 2‐deoxyglucose revealed a global reduction of brain glucose phosphorylation after metrizamide administration in the cisterna magna of rats. The reduction averaged 18% of all regions.

Original languageEnglish (US)
Pages (from-to)249-253
Number of pages5
JournalActa Neurologica Scandinavica
Volume69
Issue number4
DOIs
StatePublished - Apr 1984

Keywords

  • Brain glucose consumption
  • deoxyglucose
  • metrizamide
  • quantitative autoradiography

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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