The effect of medical male circumcision on urogenital mycoplasma genitalium among men in Kisumu, Kenya

Supriya D. Mehta, Charlotte A Gaydos, Ian MacLean, Elijah Odoyo-June, Stephen Moses, Lawrence Agunda, Nicole Quinn, Robert C. Bailey

Research output: Contribution to journalArticle

Abstract

Background: We determined the prevalence of urethral Mycoplasma genitalium (MG) infection and whether infection was associated with circumcision status among men enrolled in the randomized trial of medical male circumcision to prevent HIV acquisition in Kisumu, Kenya. Methods: MG and Trichomonas vaginalis were detected in first void urine by APTIMA transcription-mediated amplification assay. first void urine and urethral swabs were assessed for Neisseria gonorrhoeae (NG) and Chlamydia trachomatis (CT) by polymerase chain reaction assay. Herpes simplex virus type 2 antibodies were detected by IgG ELISA. Multivariable logistic regression identified factors associated with MG infection. Results: Specimens were collected between July and September 2010, and 52 (9.9%; 95% confidence interval [CI]: 7.3%-12.4%) MG infections were detected among 526 men. N. gonorrhoeae and T. vaginalis were not associated with MG. CT coinfection was 5.8% in MG-infected men, and 0.8% among MG-uninfected men (P = 0.02). MG infection was predominantly asymptomatic (98%). The prevalence of MG was 13.4% in uncircumcised men versus 8.2% in circumcised men (P = 0.06). Being circumcised nearly halved the odds of MG (adjusted odds ratio [aQR] = 0.54; 95% CI: 0.29-0.99), adjusted for other variables significant at the P <0.05 level: herpes simplex virus type 2 infection (aOR = 2.05; 95% CI: 1.05-4.00), CT infection (aOR = 2.69; 95% CI: 1.44-5.02), and washing the penis ≤1 hour after sex (aOR = 0.47; 95% CI: 0.24-0.95). Conclusions: MG infection was reduced among men who were circumcised, adding to the benefits of male circumcision in preventing several sexually transmitted infections.

Original languageEnglish (US)
Pages (from-to)276-280
Number of pages5
JournalSexually Transmitted Diseases
Volume39
Issue number4
DOIs
StatePublished - Apr 2012

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Mycoplasma genitalium
Male Circumcision
Kenya
Mycoplasma Infections
Confidence Intervals
Chlamydia trachomatis
Trichomonas vaginalis
Human Herpesvirus 2
Neisseria gonorrhoeae
Urine
Chlamydia Infections
Penis
Virus Diseases
Sexually Transmitted Diseases
Coinfection

ASJC Scopus subject areas

  • Dermatology
  • Public Health, Environmental and Occupational Health
  • Microbiology (medical)
  • Infectious Diseases

Cite this

The effect of medical male circumcision on urogenital mycoplasma genitalium among men in Kisumu, Kenya. / Mehta, Supriya D.; Gaydos, Charlotte A; MacLean, Ian; Odoyo-June, Elijah; Moses, Stephen; Agunda, Lawrence; Quinn, Nicole; Bailey, Robert C.

In: Sexually Transmitted Diseases, Vol. 39, No. 4, 04.2012, p. 276-280.

Research output: Contribution to journalArticle

Mehta, Supriya D. ; Gaydos, Charlotte A ; MacLean, Ian ; Odoyo-June, Elijah ; Moses, Stephen ; Agunda, Lawrence ; Quinn, Nicole ; Bailey, Robert C. / The effect of medical male circumcision on urogenital mycoplasma genitalium among men in Kisumu, Kenya. In: Sexually Transmitted Diseases. 2012 ; Vol. 39, No. 4. pp. 276-280.
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AU - Moses, Stephen

AU - Agunda, Lawrence

AU - Quinn, Nicole

AU - Bailey, Robert C.

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