The effect of malnutrition on the pattern of growth in the rat kidney and the renal response to acidosis

H. S. Fraser, G. A O Alleyne

Research output: Contribution to journalArticle

Abstract

1. The kidneys of normal rats were analysed for water, fat, protein, RNA and DNA, at 10, 21 and 36 d after birth. The effects on growth caused by two types of malnutrition were investigated. 2. An increase in the RNA:DNA ratio was demonstrated between 10 and 36 d, contrary to previous evidence that this ratio is fixed at birth. 3. Energy deficiency during the first 21 d of life resulted mainly in fewer kidney cells, whereas protein-energy deficiency between 21 and 36 d resulted mainly in a smaller cellular content of RNA and protein. 4. In response to metabolic acidosis, both groups of malnourished rats increased urinary excretion of ammonia and there was enhanced gluconeogenesis in vitro; the basal rate of gluconeogenesis was lower in the protein-energy-deficient rats than in the controls. 5. Protein-energy-deficient rats did not exhibit the renal hypertrophy shown by the control rats in response to acidosis.

Original languageEnglish (US)
Pages (from-to)113-124
Number of pages12
JournalBritish Journal of Nutrition
Volume31
Issue number2
DOIs
StatePublished - Jan 7 2011
Externally publishedYes

Fingerprint

Acidosis
Malnutrition
Kidney
Growth
Gluconeogenesis
RNA
Proteins
Parturition
Protein Deficiency
DNA
Ammonia
Hypertrophy
Fats
Water

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

The effect of malnutrition on the pattern of growth in the rat kidney and the renal response to acidosis. / Fraser, H. S.; Alleyne, G. A O.

In: British Journal of Nutrition, Vol. 31, No. 2, 07.01.2011, p. 113-124.

Research output: Contribution to journalArticle

@article{e49c43a63bb445ed953848815a8250dc,
title = "The effect of malnutrition on the pattern of growth in the rat kidney and the renal response to acidosis",
abstract = "1. The kidneys of normal rats were analysed for water, fat, protein, RNA and DNA, at 10, 21 and 36 d after birth. The effects on growth caused by two types of malnutrition were investigated. 2. An increase in the RNA:DNA ratio was demonstrated between 10 and 36 d, contrary to previous evidence that this ratio is fixed at birth. 3. Energy deficiency during the first 21 d of life resulted mainly in fewer kidney cells, whereas protein-energy deficiency between 21 and 36 d resulted mainly in a smaller cellular content of RNA and protein. 4. In response to metabolic acidosis, both groups of malnourished rats increased urinary excretion of ammonia and there was enhanced gluconeogenesis in vitro; the basal rate of gluconeogenesis was lower in the protein-energy-deficient rats than in the controls. 5. Protein-energy-deficient rats did not exhibit the renal hypertrophy shown by the control rats in response to acidosis.",
author = "Fraser, {H. S.} and Alleyne, {G. A O}",
year = "2011",
month = "1",
day = "7",
doi = "10.1079/BJN19740017",
language = "English (US)",
volume = "31",
pages = "113--124",
journal = "British Journal of Nutrition",
issn = "0007-1145",
publisher = "Cambridge University Press",
number = "2",

}

TY - JOUR

T1 - The effect of malnutrition on the pattern of growth in the rat kidney and the renal response to acidosis

AU - Fraser, H. S.

AU - Alleyne, G. A O

PY - 2011/1/7

Y1 - 2011/1/7

N2 - 1. The kidneys of normal rats were analysed for water, fat, protein, RNA and DNA, at 10, 21 and 36 d after birth. The effects on growth caused by two types of malnutrition were investigated. 2. An increase in the RNA:DNA ratio was demonstrated between 10 and 36 d, contrary to previous evidence that this ratio is fixed at birth. 3. Energy deficiency during the first 21 d of life resulted mainly in fewer kidney cells, whereas protein-energy deficiency between 21 and 36 d resulted mainly in a smaller cellular content of RNA and protein. 4. In response to metabolic acidosis, both groups of malnourished rats increased urinary excretion of ammonia and there was enhanced gluconeogenesis in vitro; the basal rate of gluconeogenesis was lower in the protein-energy-deficient rats than in the controls. 5. Protein-energy-deficient rats did not exhibit the renal hypertrophy shown by the control rats in response to acidosis.

AB - 1. The kidneys of normal rats were analysed for water, fat, protein, RNA and DNA, at 10, 21 and 36 d after birth. The effects on growth caused by two types of malnutrition were investigated. 2. An increase in the RNA:DNA ratio was demonstrated between 10 and 36 d, contrary to previous evidence that this ratio is fixed at birth. 3. Energy deficiency during the first 21 d of life resulted mainly in fewer kidney cells, whereas protein-energy deficiency between 21 and 36 d resulted mainly in a smaller cellular content of RNA and protein. 4. In response to metabolic acidosis, both groups of malnourished rats increased urinary excretion of ammonia and there was enhanced gluconeogenesis in vitro; the basal rate of gluconeogenesis was lower in the protein-energy-deficient rats than in the controls. 5. Protein-energy-deficient rats did not exhibit the renal hypertrophy shown by the control rats in response to acidosis.

UR - http://www.scopus.com/inward/record.url?scp=0015964966&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0015964966&partnerID=8YFLogxK

U2 - 10.1079/BJN19740017

DO - 10.1079/BJN19740017

M3 - Article

C2 - 4206858

AN - SCOPUS:0015964966

VL - 31

SP - 113

EP - 124

JO - British Journal of Nutrition

JF - British Journal of Nutrition

SN - 0007-1145

IS - 2

ER -