Abstract
1. The kidneys of normal rats were analysed for water, fat, protein, RNA and DNA, at 10, 21 and 36 d after birth. The effects on growth caused by two types of malnutrition were investigated. 2. An increase in the RNA:DNA ratio was demonstrated between 10 and 36 d, contrary to previous evidence that this ratio is fixed at birth. 3. Energy deficiency during the first 21 d of life resulted mainly in fewer kidney cells, whereas protein-energy deficiency between 21 and 36 d resulted mainly in a smaller cellular content of RNA and protein. 4. In response to metabolic acidosis, both groups of malnourished rats increased urinary excretion of ammonia and there was enhanced gluconeogenesis in vitro; the basal rate of gluconeogenesis was lower in the protein-energy-deficient rats than in the controls. 5. Protein-energy-deficient rats did not exhibit the renal hypertrophy shown by the control rats in response to acidosis.
Original language | English (US) |
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Pages (from-to) | 113-124 |
Number of pages | 12 |
Journal | British Journal of Nutrition |
Volume | 31 |
Issue number | 2 |
DOIs | |
State | Published - Jan 7 2011 |
Externally published | Yes |
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Nutrition and Dietetics