The effect of lidocaine on lysophosphatidylcholine-induced cardiac arrhythmias and cellular disturbances

Karin Jane Neufeld, C. L. Lederman, P. C. Choy, R. Y K Man

Research output: Contribution to journalArticle

Abstract

The production of arrhythmias in the isolated heart by perfusion with lysophosphatidylcholine has been well documented. However, the role of the lysophospholipid as a physiological factor in the generation of cardiac arrhythmias is not clear. In this study, a pharmacological approach was used to delineate the physiological significance of lysophosphatidylcholine during this cardiac dysfunction. Lidocaine (5-20 mg/L) was found to be effective in the protection of the isolated rat heart from the lysophospholipid-induced arrhythmias at pharmacological concentrations. The effect of lidocaine in the protection of lysophospholipid-induced membrane dysfunction was studied with red blood cells. Lidocaine (2 mg/L) protected red blood cells from hemolysis in the presence of lysophosphatidylcholine. Lidocaine did not inhibit the binding of the lysophospholipid to the red cell membrane, but inhibited hemolysis in a manner similar to cholesterol. The results are consistent with the postulate that lysophosphatidylcholine is a physiological factor in the pathogenesis of cardiac arrhythmias during myocardial ischemia.

Original languageEnglish (US)
Pages (from-to)804-808
Number of pages5
JournalCanadian Journal of Physiology and Pharmacology
Volume63
Issue number7
StatePublished - 1985
Externally publishedYes

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Lysophospholipids
Lysophosphatidylcholines
Lidocaine
Cardiac Arrhythmias
Hemolysis
Erythrocytes
Pharmacology
Myocardial Ischemia
Perfusion
Cholesterol
Cell Membrane
Membranes

ASJC Scopus subject areas

  • Physiology
  • Pharmacology

Cite this

The effect of lidocaine on lysophosphatidylcholine-induced cardiac arrhythmias and cellular disturbances. / Neufeld, Karin Jane; Lederman, C. L.; Choy, P. C.; Man, R. Y K.

In: Canadian Journal of Physiology and Pharmacology, Vol. 63, No. 7, 1985, p. 804-808.

Research output: Contribution to journalArticle

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