The effect of leptin on the ventilatory response to hyperoxia

Harald Groeben, Sascha Meier, Robert H. Brown, Christopher P. O'Donnell, Wayne Mitzner, Clarke G. Tankersley

Research output: Contribution to journalArticle

Abstract

Leptin-deficient mice show a blunted response to hypercapnia explained by central nervous system effects. The impact of leptin on peripheral chemoreceptor function is unclear. Therefore, 9 mutant (ob/ob) and 9 wild-type (+/+) mice were exposed to room air or 100% oxygen and respiratory rate (RR) and tidal volume (Vt) were measured. Subsequently, ob/ob mice received either leptin or vehicle and measurements were repeated. Compared to baseline, for +/+ mice, RR decreased significantly by 9.4% ± 3.0% (means ± SD), whereas Vt remained unchanged. Transition from normoxia to hyperoxia did not change RR and Vt in untreated ob/ob mice, whereas after leptin treatment, RR and Vt decreased significantly. Leptin deficiency abolishes the response to hyperoxia, which is restored by leptin replacement. Thus, leptin seems to be influential for a competent peripheral chemoreceptor function.

Original languageEnglish (US)
Pages (from-to)559-570
Number of pages12
JournalExperimental Lung Research
Volume30
Issue number7
DOIs
StatePublished - Oct 1 2004

Keywords

  • Mice
  • Peripheral chemoreceptor
  • Whole body plethysmography

ASJC Scopus subject areas

  • Molecular Biology
  • Pulmonary and Respiratory Medicine
  • Clinical Biochemistry

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