The effect of Kawasaki disease on cognition and behavior

W. James King, Anne Schlieper, Nina Birdi, Mario Cappelli, Yolanda Korneluk, Peter C. Rowe

Research output: Contribution to journalArticlepeer-review


Objective: To determine whether there are associated long-term deficits in the cognitive, academic, or behavioral outcomes of children with a previous episode of Kawasaki disease. Design: Cohort analytic study Setting: A tertiary care pediatric hospital in Ottawa, Ontario. Participants: Thirty- two patients with a past diagnosis of Kawasaki disease. Siblings of the patients with Kawasaki disease were eligible to be controls. Measures: A blinded psychometrist (Y.K.) assessed cognition by the appropriate Wechsler Intelligence scale, academic achievement by the Wechsler Individual Achievement Test, and behavior by the Achenbach Child Behavior Checklist. Results: No differences were found in cognitive or academic measures and the mean scores corresponded closely to national norms. Parents rated their children who had Kawasaki disease as having significantly more internalizing (P<.03) and attentional (P<02) behavior problems than controls; the risk of a clinically significant behavioral score was 3.3 times greater(P<.03; 95% confidence interval, 1.1-9.9) than for sibling controls. Conclusions: While no effect on cognitive development or academic performance was demonstrated, these results provide preliminary indication of a post-Kawasaki disease deficit in internalizing and attentional behavior.

Original languageEnglish (US)
Pages (from-to)463-468
Number of pages6
JournalArchives of Pediatrics and Adolescent Medicine
Issue number5
StatePublished - May 2000

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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