The effect of intravenous fat and total parenteral nutrition on biliary physiology

J. E. Doty, H. A. Pitt, V. Porter-Fink, L. DenBesten

Research output: Contribution to journalArticle

Abstract

Patients on long-term total parenteral nutrition (TPN) have an increased incidence of gallstones. To determine the pathophysiologic mechanisms responsible for gallstone formation in these patients, we fed three groups of prairie dogs intravenously for 10 days with continuous infusions of isocaloric, isovolemic, and isonitrogenous solution with either 0, 25, 05 50% of nonprotein calories provided as Intralipid. A fourth group of prairie dogs was hyperalimented with the 25% solution for 28 days. Control animals were fed Purina rat Chow ad libitum. Each animal's bile salt pool was labeled with iv 3H-cholic acid 16 hr prior to collecting gallbladder and hepatic bile specimens. The ratio of gallbladder to hepatic bile 3H-cholic acid specific activity (dpm/mol of bile acid), and index of gallbladder stasis, was significantly (p

Original languageEnglish (US)
Pages (from-to)263-268
Number of pages6
JournalJournal of Parenteral and Enteral Nutrition
Volume8
Issue number3
StatePublished - 1984
Externally publishedYes

Fingerprint

Total Parenteral Nutrition
gall bladder
total parenteral nutrition
Gallbladder
cholic acid
Cholic Acid
cholelithiasis
Cynomys
Sciuridae
physiology
Fats
Gallstones
bile acids
Bile Acids and Salts
Bile
lipids
liver
bile salts
Liver
bile

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)

Cite this

Doty, J. E., Pitt, H. A., Porter-Fink, V., & DenBesten, L. (1984). The effect of intravenous fat and total parenteral nutrition on biliary physiology. Journal of Parenteral and Enteral Nutrition, 8(3), 263-268.

The effect of intravenous fat and total parenteral nutrition on biliary physiology. / Doty, J. E.; Pitt, H. A.; Porter-Fink, V.; DenBesten, L.

In: Journal of Parenteral and Enteral Nutrition, Vol. 8, No. 3, 1984, p. 263-268.

Research output: Contribution to journalArticle

Doty, JE, Pitt, HA, Porter-Fink, V & DenBesten, L 1984, 'The effect of intravenous fat and total parenteral nutrition on biliary physiology', Journal of Parenteral and Enteral Nutrition, vol. 8, no. 3, pp. 263-268.
Doty, J. E. ; Pitt, H. A. ; Porter-Fink, V. ; DenBesten, L. / The effect of intravenous fat and total parenteral nutrition on biliary physiology. In: Journal of Parenteral and Enteral Nutrition. 1984 ; Vol. 8, No. 3. pp. 263-268.
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