The effect of intra-aortic balloon counterpulsation on left ventricular functional recovery early after acute myocardial infarction: A randomized experimental magnetic resonance imaging study

Clerio F. Azevedo, Luciano C. Amado, Dara L. Kraitchman, Bernhard L. Gerber, Thor Edvardsen, Nael F. Osman, Carlos E. Rochitte, Katherine C. Wu, Joao A.C. Lima

Research output: Contribution to journalArticle


Aims: We sought to determine whether intra-aortic balloon pump (IABP) counterpulsation improves the recovery of left ventricular (LV) systolic function after reperfused acute myocardial infarction (AMI). Methods and results: Fourteen dogs underwent 90-min coronary artery occlusion followed by reperfusion. Seven animals were randomized to IABP counterpulsation immediately after reperfusion. Tagged, cine, and contrast-enhanced magnetic resonance imaging were used for regional and global LV functional assessment and MI characterization, respectively. Image acquisition was performed at 1 h, 6 h, and 24 h after reperfusion, during which the IABP device was paused. Animals randomized to IABP demonstrated an earlier improvement of LV ejection fraction when compared with controls (25 ± 3 vs. 25 ± 2% at 1 h, P = 0.91; 36 ± 3 vs. 26 ± 2% at 6 h, P = 0.015; and 38 ± 3 vs. 35 ± 1% at 24 h, P = 0.34). Regional functional analyses revealed the same behaviour among non-infarcted risk regions, i.e., earlier circumferential systolic strain improvement in the IABP group than in controls (-5.4 ± 0.4 vs. -5.3 ± 0.5% at 1 h, P = 0.86; -12.1 ± 1.0 vs. -6.0 ± 0.4% at 6h, P< 0.001; and -13.9 ± 1.1% vs. -12.8 ± 0.6% at 24h, P = 0.40). Importantly, however, the degree of LV functional recovery 24 h after reperfusion was similar whether IABP counterpulsation was used or not. Conclusion: IABP counterpulsation accelerates but does not significantly improve the recovery of LV systolic function after reperfused AMI.

Original languageEnglish (US)
Pages (from-to)1235-1241
Number of pages7
JournalEuropean heart journal
Issue number12
StatePublished - Jun 1 2005



  • Intra-aortic balloon pump
  • Magnetic resonance imaging
  • Myocardial infarction
  • Myocardial stunning

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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