The effect of interleukin 38 on inflammation-induced corneal neovascularization

Jiangli Zhu, Jing Zhang, Yan Wang, Jianping Chen, Xiaopeng Li, Xiangling Liu, Eryan Kong, Shao B. Su, Zhongjian Zhang

Research output: Contribution to journalArticle

Abstract

Background: Angiogenesis is tightly linked to inflammation. Cytokines of interleukin 1 (IL-1) family are key mediators in modulating inflammatory responses. Methods: In this study, we examined the role of IL-38, a member of the IL-1 family, in mediating inflammation-induced angiogenesis. Results: The results showed that the angiogenesis was attenuated by topical administration of IL-38 to the injured corneas in a mouse model of alkali-induced corneal neovascularization (CNV). Further study showed that the expression of inflammatory cytokines TNF-α, IL-6, IL-8 and IL-1β was decreased in the IL-38-treated corneas. Moreover, the angiogenic activities including the proliferation, migration and tube formation of human retinal endothelial cells were reduced by IL-38 treatment in vitro. Conclusion: The data indicate that IL-38 modulates inflammation-induced angiogenesis.

Original languageEnglish (US)
Pages (from-to)589-596
Number of pages8
JournalCurrent Molecular Medicine
Volume19
Issue number8
DOIs
StatePublished - Jan 1 2019
Externally publishedYes

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Keywords

  • Angiogenesis
  • Cytokine
  • IL-38
  • Inflammation
  • Interleukin
  • Neovascularization

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology

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