TY - JOUR
T1 - The effect of increased intracranial pressure on vestibular evoked myogenic potentials in superior canal dehiscence syndrome
AU - Janky, Kristen L.
AU - Zuniga, M. Geraldine
AU - Schubert, Michael C.
AU - Carey, John P.
N1 - Publisher Copyright:
© 2014 International Federation of Clinical Neurophysiology.
PY - 2015/4/1
Y1 - 2015/4/1
N2 - Objective: To determine if vestibular evoked myogenic potential (VEMP) responses change during inversion in patients with superior canal dehiscence syndrome (SCDS) compared to controls. Methods: Sixteen subjects with SCDS (mean: 43, range 30-57. years) and 15 age-matched, healthy subjects (mean: 41, range 22-57. years) completed cervical VEMP (cVEMP) in response to air conduction click stimuli and ocular VEMP (oVEMP) in response to air conduction 500. Hz tone burst stimuli and midline tap stimulation. All VEMP testing was completed in semi-recumbent and inverted conditions. Results: SCDS ears demonstrated significantly larger oVEMP peak-to-peak amplitudes in comparison to normal ears in semi-recumbency. While corrected cVEMP peak-to-peak amplitudes were larger in SCDS ears; this did not reach significance in our sample. Overall, there was not a differential change in o- or cVEMP amplitude with inversion between SCDS and normal subjects. Conclusions: Postural-induced changes in o- and cVEMP responses were measured in the steady state regardless of whether the labyrinth was intact or dehiscent. Significance: VEMP responses are blunted during inversion. Although steady-state measurements of VEMPs during inversion do not increase diagnostic accuracy for SCDS, the findings suggest that inversion may provide more general insights into the equilibration of pressures between intracranial and intralabyrinthine fluids.
AB - Objective: To determine if vestibular evoked myogenic potential (VEMP) responses change during inversion in patients with superior canal dehiscence syndrome (SCDS) compared to controls. Methods: Sixteen subjects with SCDS (mean: 43, range 30-57. years) and 15 age-matched, healthy subjects (mean: 41, range 22-57. years) completed cervical VEMP (cVEMP) in response to air conduction click stimuli and ocular VEMP (oVEMP) in response to air conduction 500. Hz tone burst stimuli and midline tap stimulation. All VEMP testing was completed in semi-recumbent and inverted conditions. Results: SCDS ears demonstrated significantly larger oVEMP peak-to-peak amplitudes in comparison to normal ears in semi-recumbency. While corrected cVEMP peak-to-peak amplitudes were larger in SCDS ears; this did not reach significance in our sample. Overall, there was not a differential change in o- or cVEMP amplitude with inversion between SCDS and normal subjects. Conclusions: Postural-induced changes in o- and cVEMP responses were measured in the steady state regardless of whether the labyrinth was intact or dehiscent. Significance: VEMP responses are blunted during inversion. Although steady-state measurements of VEMPs during inversion do not increase diagnostic accuracy for SCDS, the findings suggest that inversion may provide more general insights into the equilibration of pressures between intracranial and intralabyrinthine fluids.
KW - Intracranial pressure
KW - Superior canal dehiscence
KW - Vestibular evoked myogenic potential
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U2 - 10.1016/j.clinph.2014.06.049
DO - 10.1016/j.clinph.2014.06.049
M3 - Article
C2 - 25103787
AN - SCOPUS:84924812021
SN - 1388-2457
VL - 126
SP - 780
EP - 786
JO - Clinical Neurophysiology
JF - Clinical Neurophysiology
IS - 4
ER -