The Effect of Increased Frequency of Hemodialysis on Volume-Related Outcomes: A Secondary Analysis of the Frequent Hemodialysis Network Trials

Jochen G. Raimann; Christopher T. Chan; John T. Daugirdas; Tom Depner; Frank A. Gotch; Tom Greene; George A. Kaysen; Alan S. Kliger; Peter Kotanko; Brett Larive; Robert Lindsay; Michael V. Rocco; Glenn M. Chertow; Nathan W. Levin; A. Kliger; P. Eggers; J. Briggs; T. Hostetter; A. Narva; R. Star; B. Augustine; P. Mohr; G. Beck; Z. Fu; J. Gassman; J. Daugirdas; L. Hunsicker; B. Larive; M. Li; J. MacKrell; K. Wiggins; S. Sherer; B. Weiss; S. Rajagopalan; J. Sanz; S. Dellagrottaglie; M. Kariisa; T. Tran; J. West; M. Unruh; R. Keene; J. Schlarb; M. McGrath-Chong; R. Frome; H. Higgins; S. Ke; O. Mandaci; C. Owens; C. Snell; G. Eknoyan; L. Appel; A. Cheung; A. Derse; C. Kramer; N. Geller; R. Grimm; L. Henderson; S. Prichard; E. Roecker

doi:10.1159/000441966

The Effect of Increased Frequency of Hemodialysis on Volume-Related Outcomes: A Secondary Analysis of the Frequent Hemodialysis Network Trials

Jochen G. Raimann, Christopher T. Chan, John T. Daugirdas, Tom Depner, Frank A. Gotch, Tom Greene, George A. Kaysen, Alan S. Kliger, Peter Kotanko, Brett Larive, Robert Lindsay, Michael V. Rocco, Glenn M. Chertow, Nathan W. Levin, A. Kliger, P. Eggers, J. Briggs, T. Hostetter, A. Narva, R. StarB. Augustine, P. Mohr, G. Beck, Z. Fu, J. Gassman, J. Daugirdas, L. Hunsicker, B. Larive, M. Li, J. MacKrell, K. Wiggins, S. Sherer, B. Weiss, S. Rajagopalan, J. Sanz, S. Dellagrottaglie, M. Kariisa, T. Tran, J. West, M. Unruh, R. Keene, J. Schlarb, M. McGrath-Chong, R. Frome, H. Higgins, S. Ke, O. Mandaci, C. Owens, C. Snell, G. Eknoyan, L. Appel, A. Cheung, A. Derse, C. Kramer, N. Geller, R. Grimm, L. Henderson, S. Prichard, E. Roecker

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

In previous reports of the Frequent Hemodialysis Network trials, frequent hemodialysis (HD) reduced extracellular fluid (ECF) and left ventricular mass (LVM), with more pronounced effects observed among patients with low urine volume (UVol). We analyzed the effect of frequent HD on interdialytic weight gain (IDWG) and a time-integrated estimate of ECF load (TIFL). We also explored whether volume and sodium loading contributed to the change in LVM over the study period. Treatment effects on volume parameters were analyzed for modification by UVol and the dialysate-to-serum sodium gradient. Predictors of change in LVM were determined using linear regression. Frequent HD reduced IDWG and TIFL in the Daily Trial. Among patients with UVol <100 ml/day, reduction in TIFL was associated with LVM reduction. This suggests that achievement of better volume control could attenuate changes in LVM associated with mortality and cardiovascular morbidity. TIFL may prove more useful than IDWG alone in guiding HD practice. Video Journal Club 'Cappuccino with Claudio Ronco' at http://www.karger.com/?doi=441966.

Original language	English (US)
Pages (from-to)	277-286
Number of pages	10
Journal	Blood Purification
Volume	41
Issue number	4
DOIs	https://doi.org/10.1159/000441966
State	Published - Apr 1 2016
Externally published	Yes

Keywords

Clinical trials
Fluid overload
Frequent Hemodialysis Network
Hemodialysis
Left ventricular mass

ASJC Scopus subject areas

Hematology
Nephrology

Access to Document

10.1159/000441966

Cite this

Raimann, J. G., Chan, C. T., Daugirdas, J. T., Depner, T., Gotch, F. A., Greene, T., Kaysen, G. A., Kliger, A. S., Kotanko, P., Larive, B., Lindsay, R., Rocco, M. V., Chertow, G. M., Levin, N. W., Kliger, A., Eggers, P., Briggs, J., Hostetter, T., Narva, A., ... Roecker, E. (2016). The Effect of Increased Frequency of Hemodialysis on Volume-Related Outcomes: A Secondary Analysis of the Frequent Hemodialysis Network Trials. Blood Purification, 41(4), 277-286. https://doi.org/10.1159/000441966

Raimann, JG, Chan, CT, Daugirdas, JT, Depner, T, Gotch, FA, Greene, T, Kaysen, GA, Kliger, AS, Kotanko, P, Larive, B, Lindsay, R, Rocco, MV, Chertow, GM, Levin, NW, Kliger, A, Eggers, P, Briggs, J, Hostetter, T, Narva, A, Star, R, Augustine, B, Mohr, P, Beck, G, Fu, Z, Gassman, J, Daugirdas, J, Hunsicker, L, Larive, B, Li, M, MacKrell, J, Wiggins, K, Sherer, S, Weiss, B, Rajagopalan, S, Sanz, J, Dellagrottaglie, S, Kariisa, M, Tran, T, West, J, Unruh, M, Keene, R, Schlarb, J, McGrath-Chong, M, Frome, R, Higgins, H, Ke, S, Mandaci, O, Owens, C, Snell, C, Eknoyan, G, Appel, L, Cheung, A, Derse, A, Kramer, C, Geller, N, Grimm, R, Henderson, L, Prichard, S & Roecker, E 2016, 'The Effect of Increased Frequency of Hemodialysis on Volume-Related Outcomes: A Secondary Analysis of the Frequent Hemodialysis Network Trials', Blood Purification, vol. 41, no. 4, pp. 277-286. https://doi.org/10.1159/000441966

@article{b03aa4deb0eb4d94b7b1d596782a4f0d,

title = "The Effect of Increased Frequency of Hemodialysis on Volume-Related Outcomes: A Secondary Analysis of the Frequent Hemodialysis Network Trials",

abstract = "In previous reports of the Frequent Hemodialysis Network trials, frequent hemodialysis (HD) reduced extracellular fluid (ECF) and left ventricular mass (LVM), with more pronounced effects observed among patients with low urine volume (UVol). We analyzed the effect of frequent HD on interdialytic weight gain (IDWG) and a time-integrated estimate of ECF load (TIFL). We also explored whether volume and sodium loading contributed to the change in LVM over the study period. Treatment effects on volume parameters were analyzed for modification by UVol and the dialysate-to-serum sodium gradient. Predictors of change in LVM were determined using linear regression. Frequent HD reduced IDWG and TIFL in the Daily Trial. Among patients with UVol <100 ml/day, reduction in TIFL was associated with LVM reduction. This suggests that achievement of better volume control could attenuate changes in LVM associated with mortality and cardiovascular morbidity. TIFL may prove more useful than IDWG alone in guiding HD practice. Video Journal Club 'Cappuccino with Claudio Ronco' at http://www.karger.com/?doi=441966.",

keywords = "Clinical trials, Fluid overload, Frequent Hemodialysis Network, Hemodialysis, Left ventricular mass",

author = "Raimann, {Jochen G.} and Chan, {Christopher T.} and Daugirdas, {John T.} and Tom Depner and Gotch, {Frank A.} and Tom Greene and Kaysen, {George A.} and Kliger, {Alan S.} and Peter Kotanko and Brett Larive and Robert Lindsay and Rocco, {Michael V.} and Chertow, {Glenn M.} and Levin, {Nathan W.} and A. Kliger and P. Eggers and J. Briggs and T. Hostetter and A. Narva and R. Star and B. Augustine and P. Mohr and G. Beck and Z. Fu and J. Gassman and J. Daugirdas and L. Hunsicker and B. Larive and M. Li and J. MacKrell and K. Wiggins and S. Sherer and B. Weiss and S. Rajagopalan and J. Sanz and S. Dellagrottaglie and M. Kariisa and T. Tran and J. West and M. Unruh and R. Keene and J. Schlarb and M. McGrath-Chong and R. Frome and H. Higgins and S. Ke and O. Mandaci and C. Owens and C. Snell and G. Eknoyan and L. Appel and A. Cheung and A. Derse and C. Kramer and N. Geller and R. Grimm and L. Henderson and S. Prichard and E. Roecker",

year = "2016",

month = apr,

day = "1",

doi = "10.1159/000441966",

language = "English (US)",

volume = "41",

pages = "277--286",

journal = "Blood Purification",

issn = "0253-5068",

publisher = "S. Karger AG",

number = "4",

}

TY - JOUR

T1 - The Effect of Increased Frequency of Hemodialysis on Volume-Related Outcomes

T2 - A Secondary Analysis of the Frequent Hemodialysis Network Trials

AU - Raimann, Jochen G.

AU - Chan, Christopher T.

AU - Daugirdas, John T.

AU - Depner, Tom

AU - Gotch, Frank A.

AU - Greene, Tom

AU - Kaysen, George A.

AU - Kliger, Alan S.

AU - Kotanko, Peter

AU - Larive, Brett

AU - Lindsay, Robert

AU - Rocco, Michael V.

AU - Chertow, Glenn M.

AU - Levin, Nathan W.

AU - Kliger, A.

AU - Eggers, P.

AU - Briggs, J.

AU - Hostetter, T.

AU - Narva, A.

AU - Star, R.

AU - Augustine, B.

AU - Mohr, P.

AU - Beck, G.

AU - Fu, Z.

AU - Gassman, J.

AU - Daugirdas, J.

AU - Hunsicker, L.

AU - Larive, B.

AU - Li, M.

AU - MacKrell, J.

AU - Wiggins, K.

AU - Sherer, S.

AU - Weiss, B.

AU - Rajagopalan, S.

AU - Sanz, J.

AU - Dellagrottaglie, S.

AU - Kariisa, M.

AU - Tran, T.

AU - West, J.

AU - Unruh, M.

AU - Keene, R.

AU - Schlarb, J.

AU - McGrath-Chong, M.

AU - Frome, R.

AU - Higgins, H.

AU - Ke, S.

AU - Mandaci, O.

AU - Owens, C.

AU - Snell, C.

AU - Eknoyan, G.

AU - Appel, L.

AU - Cheung, A.

AU - Derse, A.

AU - Kramer, C.

AU - Geller, N.

AU - Grimm, R.

AU - Henderson, L.

AU - Prichard, S.

AU - Roecker, E.

PY - 2016/4/1

Y1 - 2016/4/1

N2 - In previous reports of the Frequent Hemodialysis Network trials, frequent hemodialysis (HD) reduced extracellular fluid (ECF) and left ventricular mass (LVM), with more pronounced effects observed among patients with low urine volume (UVol). We analyzed the effect of frequent HD on interdialytic weight gain (IDWG) and a time-integrated estimate of ECF load (TIFL). We also explored whether volume and sodium loading contributed to the change in LVM over the study period. Treatment effects on volume parameters were analyzed for modification by UVol and the dialysate-to-serum sodium gradient. Predictors of change in LVM were determined using linear regression. Frequent HD reduced IDWG and TIFL in the Daily Trial. Among patients with UVol <100 ml/day, reduction in TIFL was associated with LVM reduction. This suggests that achievement of better volume control could attenuate changes in LVM associated with mortality and cardiovascular morbidity. TIFL may prove more useful than IDWG alone in guiding HD practice. Video Journal Club 'Cappuccino with Claudio Ronco' at http://www.karger.com/?doi=441966.

AB - In previous reports of the Frequent Hemodialysis Network trials, frequent hemodialysis (HD) reduced extracellular fluid (ECF) and left ventricular mass (LVM), with more pronounced effects observed among patients with low urine volume (UVol). We analyzed the effect of frequent HD on interdialytic weight gain (IDWG) and a time-integrated estimate of ECF load (TIFL). We also explored whether volume and sodium loading contributed to the change in LVM over the study period. Treatment effects on volume parameters were analyzed for modification by UVol and the dialysate-to-serum sodium gradient. Predictors of change in LVM were determined using linear regression. Frequent HD reduced IDWG and TIFL in the Daily Trial. Among patients with UVol <100 ml/day, reduction in TIFL was associated with LVM reduction. This suggests that achievement of better volume control could attenuate changes in LVM associated with mortality and cardiovascular morbidity. TIFL may prove more useful than IDWG alone in guiding HD practice. Video Journal Club 'Cappuccino with Claudio Ronco' at http://www.karger.com/?doi=441966.

KW - Clinical trials

KW - Fluid overload

KW - Frequent Hemodialysis Network

KW - Hemodialysis

KW - Left ventricular mass

UR - http://www.scopus.com/inward/record.url?scp=84955616973&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84955616973&partnerID=8YFLogxK

U2 - 10.1159/000441966

DO - 10.1159/000441966

M3 - Article

C2 - 26795100

AN - SCOPUS:84955616973

SN - 0253-5068

VL - 41

SP - 277

EP - 286

JO - Blood Purification

JF - Blood Purification

IS - 4

ER -

The Effect of Increased Frequency of Hemodialysis on Volume-Related Outcomes: A Secondary Analysis of the Frequent Hemodialysis Network Trials

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this