The effect of in vitro fertilization on gingival inflammation according to women's periodontal status

clinical data.

Anthodesmi Pavlatou, Alexandra Tsami, Nicolaos Vlahos, Themis Mantzavinos, Ioannis Vrotsos

Research output: Contribution to journalArticle

Abstract

To study whether in vitrofertilization (IVF) treatment has any effect on women's preexisting periodontal status and, if pre-existing women's periodontal status has any impact on IVF outcomes, such as superovulation for multiple follicles maturation, oocyte retrieval and embryo transfer, as well as on pregnancy and its outcomes. Sixty women aged 29 to 41 years were recruited in the study. Gingival inflammation (simplified gingival index, GI-S), plaque levels (plaque control record index, PCR), bleeding on probing (BOP) and probing depth (PD), were recorded for all participants before and after IVF. Blood tests were performed prior to IVF. A statistically significant increase in GI-S after IVF was observed in all women (31.9 +/- 18.7% to 61.7 +/- 23.5%), and was higher in women with gingivitis (37.1 +/- 5.7% to 77.6 +/- 6.7%). Women with periodontitis demonstrated a statistically significant increase in BOP (67.7 +/- 6.6% to 89.5 +/- 7.1%), and in the sum of probing pocket depths (from 243.8 +/- 56.2 mm to 250.5 +/- 58.3 mm). A trend for negative correlation between the number of follicles and transferred embryos and the gingival index, before and after IVF respectively, was recorded in all women. There was a similar trend with bleeding on probing after IVF in women with periodontitis. Periodontal clinical parameters worsened in women undergoing IVF treatment. On the other hand, a poor pre-existing periodontal status seems to be associated with poorer outcomes of IVF treatment.

Original languageEnglish (US)
Pages (from-to)36-42
Number of pages7
JournalJournal of the International Academy of Periodontology
Volume15
Issue number2
StatePublished - Apr 2013
Externally publishedYes

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Women's Rights
Fertilization in Vitro
Inflammation
Periodontal Index
Periodontitis
Hemorrhage
Superovulation
Oocyte Retrieval
Gingivitis
Embryo Transfer
Hematologic Tests
Pregnancy Outcome
Therapeutics
Embryonic Structures

ASJC Scopus subject areas

  • Medicine(all)

Cite this

The effect of in vitro fertilization on gingival inflammation according to women's periodontal status : clinical data. / Pavlatou, Anthodesmi; Tsami, Alexandra; Vlahos, Nicolaos; Mantzavinos, Themis; Vrotsos, Ioannis.

In: Journal of the International Academy of Periodontology, Vol. 15, No. 2, 04.2013, p. 36-42.

Research output: Contribution to journalArticle

Pavlatou, Anthodesmi ; Tsami, Alexandra ; Vlahos, Nicolaos ; Mantzavinos, Themis ; Vrotsos, Ioannis. / The effect of in vitro fertilization on gingival inflammation according to women's periodontal status : clinical data. In: Journal of the International Academy of Periodontology. 2013 ; Vol. 15, No. 2. pp. 36-42.
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abstract = "To study whether in vitrofertilization (IVF) treatment has any effect on women's preexisting periodontal status and, if pre-existing women's periodontal status has any impact on IVF outcomes, such as superovulation for multiple follicles maturation, oocyte retrieval and embryo transfer, as well as on pregnancy and its outcomes. Sixty women aged 29 to 41 years were recruited in the study. Gingival inflammation (simplified gingival index, GI-S), plaque levels (plaque control record index, PCR), bleeding on probing (BOP) and probing depth (PD), were recorded for all participants before and after IVF. Blood tests were performed prior to IVF. A statistically significant increase in GI-S after IVF was observed in all women (31.9 +/- 18.7{\%} to 61.7 +/- 23.5{\%}), and was higher in women with gingivitis (37.1 +/- 5.7{\%} to 77.6 +/- 6.7{\%}). Women with periodontitis demonstrated a statistically significant increase in BOP (67.7 +/- 6.6{\%} to 89.5 +/- 7.1{\%}), and in the sum of probing pocket depths (from 243.8 +/- 56.2 mm to 250.5 +/- 58.3 mm). A trend for negative correlation between the number of follicles and transferred embryos and the gingival index, before and after IVF respectively, was recorded in all women. There was a similar trend with bleeding on probing after IVF in women with periodontitis. Periodontal clinical parameters worsened in women undergoing IVF treatment. On the other hand, a poor pre-existing periodontal status seems to be associated with poorer outcomes of IVF treatment.",
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