The Effect of Hypothermic Preservation of the Heart and Lungs on Cardiorespiratory Function Following Canine Heart-Lung Transplantation

Thomas W. Feeley; Frederick G. Mihm; T. Peter Downing; Ali M. Sadeghi; William A. Baumgartner; Bruce A. Reitz; Norman E. Shumway

doi:10.1016/S0003-4975(10)61998-4

The Effect of Hypothermic Preservation of the Heart and Lungs on Cardiorespiratory Function Following Canine Heart-Lung Transplantation

Thomas W. Feeley, Frederick G. Mihm, T. Peter Downing, Ali M. Sadeghi, William A. Baumgartner, Bruce A. Reitz, Norman E. Shumway

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

The effect of hypothermic preservation of the heart and lungs with a crystalloid solution was evaluated in 12 mongrel dogs receiving heart-lung allografts. Six animals served as controls and received an immediate heart-lung transplant. Six animals were in the experimental group and received a heart-lung transplant after 5 hours of preservation at 4°C following perfusion of both organs with a crystalloid solution. Physiological function of the heart and lungs was studied for 20 hours after transplantation. While cardiac function was minimally depressed following preservation, pulmonary function testing demonstrated significantly greater increases in extravascular lung water in experimental animals, suggesting that an ischemic lung injury occurred with this preservation technique. The model allows for future evaluation of other methods of combined preservation of both the heart and lungs for transplantation.

Original language	English (US)
Pages (from-to)	558-562
Number of pages	5
Journal	Annals of Thoracic Surgery
Volume	39
Issue number	6
DOIs	https://doi.org/10.1016/S0003-4975(10)61998-4
State	Published - 1985
Externally published	Yes

ASJC Scopus subject areas

Surgery
Pulmonary and Respiratory Medicine
Cardiology and Cardiovascular Medicine

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10.1016/S0003-4975(10)61998-4

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@article{7a2590932e9a439faacbb1871e756dc8,

title = "The Effect of Hypothermic Preservation of the Heart and Lungs on Cardiorespiratory Function Following Canine Heart-Lung Transplantation",

abstract = "The effect of hypothermic preservation of the heart and lungs with a crystalloid solution was evaluated in 12 mongrel dogs receiving heart-lung allografts. Six animals served as controls and received an immediate heart-lung transplant. Six animals were in the experimental group and received a heart-lung transplant after 5 hours of preservation at 4°C following perfusion of both organs with a crystalloid solution. Physiological function of the heart and lungs was studied for 20 hours after transplantation. While cardiac function was minimally depressed following preservation, pulmonary function testing demonstrated significantly greater increases in extravascular lung water in experimental animals, suggesting that an ischemic lung injury occurred with this preservation technique. The model allows for future evaluation of other methods of combined preservation of both the heart and lungs for transplantation.",

author = "Feeley, {Thomas W.} and Mihm, {Frederick G.} and Downing, {T. Peter} and Sadeghi, {Ali M.} and Baumgartner, {William A.} and Reitz, {Bruce A.} and Shumway, {Norman E.}",

note = "Funding Information: Supported in part by Grant HL08696 from the National Institutes of Health. The authors thank Mr. Grant Hoyt and Mr. Julian Ashton for technical assistance and Ms. Marian Lykken, Ms. Roz Mandell, and Ms. Norma Garcia for the preparation of the manuscript.",

year = "1985",

doi = "10.1016/S0003-4975(10)61998-4",

language = "English (US)",

volume = "39",

pages = "558--562",

journal = "Annals of Thoracic Surgery",

issn = "0003-4975",

publisher = "Elsevier USA",

number = "6",

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T1 - The Effect of Hypothermic Preservation of the Heart and Lungs on Cardiorespiratory Function Following Canine Heart-Lung Transplantation

AU - Feeley, Thomas W.

AU - Mihm, Frederick G.

AU - Downing, T. Peter

AU - Sadeghi, Ali M.

AU - Baumgartner, William A.

AU - Reitz, Bruce A.

AU - Shumway, Norman E.

N1 - Funding Information: Supported in part by Grant HL08696 from the National Institutes of Health. The authors thank Mr. Grant Hoyt and Mr. Julian Ashton for technical assistance and Ms. Marian Lykken, Ms. Roz Mandell, and Ms. Norma Garcia for the preparation of the manuscript.

PY - 1985

Y1 - 1985

N2 - The effect of hypothermic preservation of the heart and lungs with a crystalloid solution was evaluated in 12 mongrel dogs receiving heart-lung allografts. Six animals served as controls and received an immediate heart-lung transplant. Six animals were in the experimental group and received a heart-lung transplant after 5 hours of preservation at 4°C following perfusion of both organs with a crystalloid solution. Physiological function of the heart and lungs was studied for 20 hours after transplantation. While cardiac function was minimally depressed following preservation, pulmonary function testing demonstrated significantly greater increases in extravascular lung water in experimental animals, suggesting that an ischemic lung injury occurred with this preservation technique. The model allows for future evaluation of other methods of combined preservation of both the heart and lungs for transplantation.

AB - The effect of hypothermic preservation of the heart and lungs with a crystalloid solution was evaluated in 12 mongrel dogs receiving heart-lung allografts. Six animals served as controls and received an immediate heart-lung transplant. Six animals were in the experimental group and received a heart-lung transplant after 5 hours of preservation at 4°C following perfusion of both organs with a crystalloid solution. Physiological function of the heart and lungs was studied for 20 hours after transplantation. While cardiac function was minimally depressed following preservation, pulmonary function testing demonstrated significantly greater increases in extravascular lung water in experimental animals, suggesting that an ischemic lung injury occurred with this preservation technique. The model allows for future evaluation of other methods of combined preservation of both the heart and lungs for transplantation.

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JO - Annals of Thoracic Surgery

JF - Annals of Thoracic Surgery

IS - 6

ER -

The Effect of Hypothermic Preservation of the Heart and Lungs on Cardiorespiratory Function Following Canine Heart-Lung Transplantation

Abstract

ASJC Scopus subject areas

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