The effect of hypothermic preservation of the heart and lungs on cardiorespiratory function following canine heart-lung transplantation

T. W. Feeley, F. G. Mihm, T. P. Downing, A. M. Sadeghi, William A Baumgartner, B. A. Reitz, N. E. Shumway

Research output: Contribution to journalArticle

Abstract

The effect of hypothermic preservation of the heart and lungs with a crystalloid solution was evaluated in 12 mongrel dogs receiving heart-lung allografts. Six animals served as controls and received an immediate heart-lung transplant. Six animals were in the experimental group and received a heart-lung transplant after 5 hours of preservation at 4° C following perfusion of both organs with a crystalloid solution. Physiological function of the heart and lungs was studied for 20 hours after transplantation. While cardiac function was minimally depressed following preservation, pulmonary function testing demonstrated significantly greater increases in extravascular lung water in experimental animals, suggesting that an ischemic lung injury occurred with this preservation technique. The model allows for future evaluation of other methods of combined preservation of both the heart and lungs for transplantation.

Original languageEnglish (US)
Pages (from-to)558-562
Number of pages5
JournalAnnals of Thoracic Surgery
Volume39
Issue number6
StatePublished - 1985
Externally publishedYes

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Heart-Lung Transplantation
Canidae
Lung
Extravascular Lung Water
Transplants
Lung Injury
Allografts
Perfusion
Transplantation
Dogs

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery

Cite this

The effect of hypothermic preservation of the heart and lungs on cardiorespiratory function following canine heart-lung transplantation. / Feeley, T. W.; Mihm, F. G.; Downing, T. P.; Sadeghi, A. M.; Baumgartner, William A; Reitz, B. A.; Shumway, N. E.

In: Annals of Thoracic Surgery, Vol. 39, No. 6, 1985, p. 558-562.

Research output: Contribution to journalArticle

Feeley, T. W. ; Mihm, F. G. ; Downing, T. P. ; Sadeghi, A. M. ; Baumgartner, William A ; Reitz, B. A. ; Shumway, N. E. / The effect of hypothermic preservation of the heart and lungs on cardiorespiratory function following canine heart-lung transplantation. In: Annals of Thoracic Surgery. 1985 ; Vol. 39, No. 6. pp. 558-562.
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