The effect of hypothermia on aqueous humor dynamics. I. Intraocular pressure and outflow facility of the rabbit eye

Irvin P. Pollack; Bernard Becker; Marguerite A. Constant

The effect of hypothermia on aqueous humor dynamics. I. Intraocular pressure and outflow facility of the rabbit eye

Irvin P. Pollack, Bernard Becker, Marguerite A. Constant

Research output: Contribution to journal › Article › peer-review

Abstract

Intraocular pressure fell logarithmically with decline in rectal temperature during immersion hypothermia in rabbits. The first significant fall appeared at 33 °C. and the pressure was halved for every 20.5 °C. fall in body temperature thereafter. The temperature coefficient (Q₁₀) of this process was found to be 1.4. A decrease in the facility of outflow occurred during hypothermia as demonstrated by tonography and perfusion in vivo and in vitro. However, this fall could be entirely accounted for by the changes in viscosity of water with temperature. Aqueous flow decreased 80 to 90 percent al 19 °C. as estimated by comparative tonometric and tonographic studies of normothermic and hypothermic rabbits. For every 7 °C. fall in body temperature, the flow rate was halved.

Original language	English (US)
Pages (from-to)	1126-1134
Number of pages	9
Journal	American journal of ophthalmology
Volume	49
Issue number	5 PART 2
State	Published - May 1960
Externally published	Yes

ASJC Scopus subject areas

Ophthalmology

Cite this

@article{fea2092295cc427295a3367cd8b97006,

title = "The effect of hypothermia on aqueous humor dynamics. I. Intraocular pressure and outflow facility of the rabbit eye",

abstract = "Intraocular pressure fell logarithmically with decline in rectal temperature during immersion hypothermia in rabbits. The first significant fall appeared at 33 °C. and the pressure was halved for every 20.5 °C. fall in body temperature thereafter. The temperature coefficient (Q10) of this process was found to be 1.4. A decrease in the facility of outflow occurred during hypothermia as demonstrated by tonography and perfusion in vivo and in vitro. However, this fall could be entirely accounted for by the changes in viscosity of water with temperature. Aqueous flow decreased 80 to 90 percent al 19 °C. as estimated by comparative tonometric and tonographic studies of normothermic and hypothermic rabbits. For every 7 °C. fall in body temperature, the flow rate was halved.",

author = "Pollack, {Irvin P.} and Bernard Becker and Constant, {Marguerite A.}",

note = "Funding Information: *From the Department of Ophthalmology and the Oscar Johnson Institute, Washington University School of Medicine. This investigation was supported in part by a research grant, B-621, from the National Institute of Neurological Diseases and Blindness of the National Institutes of Health, Public Health Service.",

year = "1960",

month = may,

language = "English (US)",

volume = "49",

pages = "1126--1134",

journal = "American journal of ophthalmology",

issn = "0002-9394",

publisher = "Elsevier USA",

number = "5 PART 2",

}

TY - JOUR

T1 - The effect of hypothermia on aqueous humor dynamics. I. Intraocular pressure and outflow facility of the rabbit eye

AU - Pollack, Irvin P.

AU - Becker, Bernard

AU - Constant, Marguerite A.

N1 - Funding Information: *From the Department of Ophthalmology and the Oscar Johnson Institute, Washington University School of Medicine. This investigation was supported in part by a research grant, B-621, from the National Institute of Neurological Diseases and Blindness of the National Institutes of Health, Public Health Service.

PY - 1960/5

Y1 - 1960/5

N2 - Intraocular pressure fell logarithmically with decline in rectal temperature during immersion hypothermia in rabbits. The first significant fall appeared at 33 °C. and the pressure was halved for every 20.5 °C. fall in body temperature thereafter. The temperature coefficient (Q10) of this process was found to be 1.4. A decrease in the facility of outflow occurred during hypothermia as demonstrated by tonography and perfusion in vivo and in vitro. However, this fall could be entirely accounted for by the changes in viscosity of water with temperature. Aqueous flow decreased 80 to 90 percent al 19 °C. as estimated by comparative tonometric and tonographic studies of normothermic and hypothermic rabbits. For every 7 °C. fall in body temperature, the flow rate was halved.

AB - Intraocular pressure fell logarithmically with decline in rectal temperature during immersion hypothermia in rabbits. The first significant fall appeared at 33 °C. and the pressure was halved for every 20.5 °C. fall in body temperature thereafter. The temperature coefficient (Q10) of this process was found to be 1.4. A decrease in the facility of outflow occurred during hypothermia as demonstrated by tonography and perfusion in vivo and in vitro. However, this fall could be entirely accounted for by the changes in viscosity of water with temperature. Aqueous flow decreased 80 to 90 percent al 19 °C. as estimated by comparative tonometric and tonographic studies of normothermic and hypothermic rabbits. For every 7 °C. fall in body temperature, the flow rate was halved.

UR - http://www.scopus.com/inward/record.url?scp=0003175087&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0003175087&partnerID=8YFLogxK

M3 - Article

C2 - 14433835

AN - SCOPUS:0003175087

SN - 0002-9394

VL - 49

SP - 1126

EP - 1134

JO - American journal of ophthalmology

JF - American journal of ophthalmology

IS - 5 PART 2

ER -

The effect of hypothermia on aqueous humor dynamics. I. Intraocular pressure and outflow facility of the rabbit eye

Abstract

ASJC Scopus subject areas

Other files and links

Fingerprint

Cite this