The effect of hydrocortisone on lamb lung function

J. W.C. Johnson, H. S. Limb, K. Kearney, H. Abbey, G. H. Brumley, C. J. Migeon, P. A. Lee, R. Scott

Research output: Contribution to journalArticlepeer-review

Abstract

In this study, administration of hydrocortisone to fetal lambs was associated with an increase in lung volume, but alterations in fetal lung surfactant (as measured by alveolar stability, lung extract surface tensions and phosphatidylcholine concentrations) were not discerned. Our findings support recent rhesus monkey studies suggesting that the principal effect of glucocorticoids is upon nonsurfactant components of the lung.

Original languageEnglish (US)
Pages (from-to)413-420
Number of pages8
JournalJournal of Reproductive Medicine for the Obstetrician and Gynecologist
Volume26
Issue number8
StatePublished - 1981

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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