The effect of hydrocortisone on lamb lung function

J. W.C. Johnson; H. S. Limb; K. Kearney; H. Abbey; G. H. Brumley; C. J. Migeon; P. A. Lee; R. Scott

The effect of hydrocortisone on lamb lung function

J. W.C. Johnson, H. S. Limb, K. Kearney, H. Abbey, G. H. Brumley, C. J. Migeon, P. A. Lee, R. Scott

School of Medicine

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

In this study, administration of hydrocortisone to fetal lambs was associated with an increase in lung volume, but alterations in fetal lung surfactant (as measured by alveolar stability, lung extract surface tensions and phosphatidylcholine concentrations) were not discerned. Our findings support recent rhesus monkey studies suggesting that the principal effect of glucocorticoids is upon nonsurfactant components of the lung.

Original language	English (US)
Pages (from-to)	413-420
Number of pages	8
Journal	Journal of Reproductive Medicine for the Obstetrician and Gynecologist
Volume	26
Issue number	8
State	Published - 1981

ASJC Scopus subject areas

Reproductive Medicine
Obstetrics and Gynecology

Cite this

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title = "The effect of hydrocortisone on lamb lung function",

abstract = "In this study, administration of hydrocortisone to fetal lambs was associated with an increase in lung volume, but alterations in fetal lung surfactant (as measured by alveolar stability, lung extract surface tensions and phosphatidylcholine concentrations) were not discerned. Our findings support recent rhesus monkey studies suggesting that the principal effect of glucocorticoids is upon nonsurfactant components of the lung.",

author = "Johnson, {J. W.C.} and Limb, {H. S.} and K. Kearney and H. Abbey and Brumley, {G. H.} and Migeon, {C. J.} and Lee, {P. A.} and R. Scott",

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language = "English (US)",

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AU - Johnson, J. W.C.

AU - Limb, H. S.

AU - Kearney, K.

AU - Abbey, H.

AU - Brumley, G. H.

AU - Migeon, C. J.

AU - Lee, P. A.

AU - Scott, R.

PY - 1981

Y1 - 1981

N2 - In this study, administration of hydrocortisone to fetal lambs was associated with an increase in lung volume, but alterations in fetal lung surfactant (as measured by alveolar stability, lung extract surface tensions and phosphatidylcholine concentrations) were not discerned. Our findings support recent rhesus monkey studies suggesting that the principal effect of glucocorticoids is upon nonsurfactant components of the lung.

AB - In this study, administration of hydrocortisone to fetal lambs was associated with an increase in lung volume, but alterations in fetal lung surfactant (as measured by alveolar stability, lung extract surface tensions and phosphatidylcholine concentrations) were not discerned. Our findings support recent rhesus monkey studies suggesting that the principal effect of glucocorticoids is upon nonsurfactant components of the lung.

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AN - SCOPUS:0019419096

SN - 0024-7758

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JF - Journal of Reproductive Medicine for the Obstetrician and Gynecologist

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ER -

The effect of hydrocortisone on lamb lung function

Abstract

ASJC Scopus subject areas

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