The Effect of Highly Active Antiretroviral Therapy on Dermatologic Disease in a Longitudinal Study of HIV Type 1-Infected Women

Toby Maurer, Lori K.E. Rodrigues, Niloufar Ameli, Nittaya Phanuphak, Stephen J. Gange, Jack DeHovitz, Audrey L. French, Marshall Glesby, Carol Jordan, Ann Khalsa, Nancy A. Hessol

Research output: Contribution to journalArticle

Abstract

The effect of highly active antiretroviral therapy (HAART) on skin diseases was evaluated in 878 human immunodeficiency virus type 1 (HIV-1)-infected women in the Women's Interagency HIV Study, a multicenter prospective study. HIV-1-infected women receiving HAART were less likely to have eczema, folliculitis, tinea pedis, and xerosis than were women who had not initiated HAART, independent of CD4+ cell count. Participants who had a prior history of a nadir CD4+ cell count of <200 cells/ μL and recent CD4+ cell counts of 200-349 cells/μL were more likely to have eczema and xerosis than were women with a nadir CD4+ cell count of >200 cells/μL and recent CD4+ cell counts of >349 cells/μL. An HIV-1 RNA load of >100,000 copies/mL was associated with increased prevalence of herpes zoster infection (odds ratio, 6.10; 95% confidence interval, 2.00-18.65). History of injection drug use was associated with a higher prevalence of onychomycosis, tinea pedis, and xerosis. Molluscum contagiosum was more prevalent among younger women.

Original languageEnglish (US)
Pages (from-to)579-584
Number of pages6
JournalClinical Infectious Diseases
Volume38
Issue number4
DOIs
StatePublished - Feb 15 2004

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ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Cite this

Maurer, T., Rodrigues, L. K. E., Ameli, N., Phanuphak, N., Gange, S. J., DeHovitz, J., French, A. L., Glesby, M., Jordan, C., Khalsa, A., & Hessol, N. A. (2004). The Effect of Highly Active Antiretroviral Therapy on Dermatologic Disease in a Longitudinal Study of HIV Type 1-Infected Women. Clinical Infectious Diseases, 38(4), 579-584. https://doi.org/10.1086/381264