The effect of hepatocellular carcinoma surveillance in an urban population with liver cirrhosis

Jeffrey D. Nusbaum, John Smirniotopoulos, Henry C. Wright, Chiranjeev Dash, Tarina Parpia, Joanna Shechtel, Yaojen Chang, Christopher Loffredo, Kirti Shetty

Research output: Contribution to journalArticle

Abstract

Background: Hepatocellular carcinoma (HCC) surveillance in patients with cirrhosis is aimed at early detection so that effective therapeutic options may be offered. We undertook this study to assess the patterns of surveillance that had been offered to HCC patients evaluated at our center, and the effect of these strategies on outcome. Methods: Consecutive patients, age 18 years and older, diagnosed with HCC between December 2007 and December 2012 were identified. Surveillance was defined as a-fetoprotein measurement and/or imaging examination in the 12 months before HCC diagnosis. Logistic regression and survival analysis models were utilized to investigate the association of surveillance with patient characteristics and survival. Results: A total of 305 patients with HCC and a background of cirrhosis were analyzed. HCC was detected by surveillance in 131 patients (43%). Of those who underwent surveillance, 92% were diagnosed with early-stage cancer (stages I and II) compared with 62% of those who did not undergo surveillance (P

Original languageEnglish (US)
Pages (from-to)e91-e95
JournalJournal of Clinical Gastroenterology
Volume49
Issue number10
StatePublished - Oct 9 2015

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Urban Population
Liver Cirrhosis
Hepatocellular Carcinoma
Fibrosis
Fetal Proteins
Survival Analysis
Logistic Models
Regression Analysis
Survival
Neoplasms

Keywords

  • Cirrhosis
  • Hepatocellular carcinoma
  • Surveillance

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Nusbaum, J. D., Smirniotopoulos, J., Wright, H. C., Dash, C., Parpia, T., Shechtel, J., ... Shetty, K. (2015). The effect of hepatocellular carcinoma surveillance in an urban population with liver cirrhosis. Journal of Clinical Gastroenterology, 49(10), e91-e95.

The effect of hepatocellular carcinoma surveillance in an urban population with liver cirrhosis. / Nusbaum, Jeffrey D.; Smirniotopoulos, John; Wright, Henry C.; Dash, Chiranjeev; Parpia, Tarina; Shechtel, Joanna; Chang, Yaojen; Loffredo, Christopher; Shetty, Kirti.

In: Journal of Clinical Gastroenterology, Vol. 49, No. 10, 09.10.2015, p. e91-e95.

Research output: Contribution to journalArticle

Nusbaum, JD, Smirniotopoulos, J, Wright, HC, Dash, C, Parpia, T, Shechtel, J, Chang, Y, Loffredo, C & Shetty, K 2015, 'The effect of hepatocellular carcinoma surveillance in an urban population with liver cirrhosis', Journal of Clinical Gastroenterology, vol. 49, no. 10, pp. e91-e95.
Nusbaum JD, Smirniotopoulos J, Wright HC, Dash C, Parpia T, Shechtel J et al. The effect of hepatocellular carcinoma surveillance in an urban population with liver cirrhosis. Journal of Clinical Gastroenterology. 2015 Oct 9;49(10):e91-e95.
Nusbaum, Jeffrey D. ; Smirniotopoulos, John ; Wright, Henry C. ; Dash, Chiranjeev ; Parpia, Tarina ; Shechtel, Joanna ; Chang, Yaojen ; Loffredo, Christopher ; Shetty, Kirti. / The effect of hepatocellular carcinoma surveillance in an urban population with liver cirrhosis. In: Journal of Clinical Gastroenterology. 2015 ; Vol. 49, No. 10. pp. e91-e95.
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