The effect of HAART-induced HIV suppression on circulating markers of inflammation and immune activation

Nikolas Itaru Wada, Lisa P. Jacobson, Joseph B. Margolick, Elizabeth Crabb Breen, Bernard Macatangay, Sudhir Penugonda, Otoniel Martínez-Maza, Jay H. Bream

Research output: Contribution to journalArticle

Abstract

OBJECTIVES:: To investigate the impact of HAART-induced HIV suppression on levels of 24 serological biomarkers of inflammation and immune activation. DESIGN:: A prospective cohort study. METHODS:: Biomarkers were measured with multiplex assays in centralized laboratories using stored serum samples contributed by 1697 men during 8903 person-visits in the Multicenter AIDS Cohort Study (MACS) from 1984 to 2009. Using generalized gamma models, we compared biomarker values across three groups, adjusting for possible confounders: HIV-uninfected (NEG); HIV-positive, HAART-naive (NAI); and HAART-exposed with HIV RNA suppressed to less than 50copies/ml plasma (SUP). We also estimated changes in biomarker levels associated with duration of HIV suppression, using splined generalized gamma regression with a knot at 1 year. RESULTS:: Most biomarkers were relatively normalized in the SUP group relative to the NAI group; however, 12 biomarkers in the SUP group were distinct (P<0.002) from NEG values: CXCL10, C-reactive protein (CRP), sCD14, sTNFR2, tumour necrosis factor-alpha (TNF-α), sCD27, sGP130, interleukin (IL)-8, CCL13, BAFF, GM-CSF and IL-12p70. Thirteen biomarkers exhibited significant changes in the first year after viral suppression, but none changed significantly after that time. CONCLUSION:: Biomarkers of inflammation and immune activation moved towards HIV-negative levels within the first year after HAART-induced HIV suppression. Although several markers of T-cell activation returned to levels present in HIV-negative men, residual immune activation, particularly monocyte/macrophage activation, was present. This residual immune activation may represent a therapeutic target to improve the prognosis of HIV-infected individuals receiving HAART..

Original languageEnglish (US)
Pages (from-to)463-471
Number of pages9
JournalAIDS
Volume29
Issue number4
DOIs
StatePublished - Feb 20 2015

Keywords

  • AIDS
  • antiretroviral therapy
  • biological markers
  • inflammation
  • male
  • prospective studies

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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