Abstract
The potential for postoperative complications in irradiated intestinal anastomoses is well known. There has been limited evaluation of factors that may improve wound healing in radiation-injured bowel. Growth hormone (GH) has been shown to improve wound healing. In animal models GH has been demonstrated to increase strength of large bowel anastomoses in nonirradiated bowel. The purpose of this study was to evaluate, in a rat model, the effect of GH on the bursting pressure of radiation-injured terminal ileal anastomoses in a rat model. Fifty-four rats were treated with 1700 cGy of pelvic irradiation in a single dose. Seventeen weeks later resection of a segment of terminal ileum and an ileo-ileostomy was performed. Half the rats received GH (2.0 mg/kg/day) and the rest received normal saline subcutaneously for 7 days starting on the day of surgery. On the seventh postoperative day the anastomosis site was identified at reoperation and bursting pressure was measured in vivo. A significantly greater bursting pressure was observed in the GH-treated rats compared to the control group (208.9 ± 27 cm H2O vs 177 ± 53 cm H2O, P <0.025). GH treatment resulted in an 18% greater strength of radiation-injured terminal ileal anastomotic segments, as measured by bursting pressure. These findings suggest a possible role for GH in decreasing the morbidity in patients who undergo intestinal surgery after radiation treatment.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 121-122 |
| Number of pages | 2 |
| Journal | Gynecologic Oncology |
| Volume | 70 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jul 1998 |
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ASJC Scopus subject areas
- Obstetrics and Gynecology
- Oncology
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The effect of growth hormone on the bursting strength of ileal anastomotic segments in radiation-injured rat bowel. / Wheeless, Clifford R.; Zanagnolo, Vanna; Bowers, Deborah; Brenner, Mark J.; Lilley, Robin.
In: Gynecologic Oncology, Vol. 70, No. 1, 07.1998, p. 121-122.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The effect of growth hormone on the bursting strength of ileal anastomotic segments in radiation-injured rat bowel
AU - Wheeless, Clifford R.
AU - Zanagnolo, Vanna
AU - Bowers, Deborah
AU - Brenner, Mark J.
AU - Lilley, Robin
PY - 1998/7
Y1 - 1998/7
N2 - The potential for postoperative complications in irradiated intestinal anastomoses is well known. There has been limited evaluation of factors that may improve wound healing in radiation-injured bowel. Growth hormone (GH) has been shown to improve wound healing. In animal models GH has been demonstrated to increase strength of large bowel anastomoses in nonirradiated bowel. The purpose of this study was to evaluate, in a rat model, the effect of GH on the bursting pressure of radiation-injured terminal ileal anastomoses in a rat model. Fifty-four rats were treated with 1700 cGy of pelvic irradiation in a single dose. Seventeen weeks later resection of a segment of terminal ileum and an ileo-ileostomy was performed. Half the rats received GH (2.0 mg/kg/day) and the rest received normal saline subcutaneously for 7 days starting on the day of surgery. On the seventh postoperative day the anastomosis site was identified at reoperation and bursting pressure was measured in vivo. A significantly greater bursting pressure was observed in the GH-treated rats compared to the control group (208.9 ± 27 cm H2O vs 177 ± 53 cm H2O, P <0.025). GH treatment resulted in an 18% greater strength of radiation-injured terminal ileal anastomotic segments, as measured by bursting pressure. These findings suggest a possible role for GH in decreasing the morbidity in patients who undergo intestinal surgery after radiation treatment.
AB - The potential for postoperative complications in irradiated intestinal anastomoses is well known. There has been limited evaluation of factors that may improve wound healing in radiation-injured bowel. Growth hormone (GH) has been shown to improve wound healing. In animal models GH has been demonstrated to increase strength of large bowel anastomoses in nonirradiated bowel. The purpose of this study was to evaluate, in a rat model, the effect of GH on the bursting pressure of radiation-injured terminal ileal anastomoses in a rat model. Fifty-four rats were treated with 1700 cGy of pelvic irradiation in a single dose. Seventeen weeks later resection of a segment of terminal ileum and an ileo-ileostomy was performed. Half the rats received GH (2.0 mg/kg/day) and the rest received normal saline subcutaneously for 7 days starting on the day of surgery. On the seventh postoperative day the anastomosis site was identified at reoperation and bursting pressure was measured in vivo. A significantly greater bursting pressure was observed in the GH-treated rats compared to the control group (208.9 ± 27 cm H2O vs 177 ± 53 cm H2O, P <0.025). GH treatment resulted in an 18% greater strength of radiation-injured terminal ileal anastomotic segments, as measured by bursting pressure. These findings suggest a possible role for GH in decreasing the morbidity in patients who undergo intestinal surgery after radiation treatment.
UR - http://www.scopus.com/inward/record.url?scp=0032126802&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032126802&partnerID=8YFLogxK
U2 - 10.1006/gyno.1998.5045
DO - 10.1006/gyno.1998.5045
M3 - Article
C2 - 9698487
AN - SCOPUS:0032126802
VL - 70
SP - 121
EP - 122
JO - Gynecologic Oncology
JF - Gynecologic Oncology
SN - 0090-8258
IS - 1
ER -