The effect of geometry on tumor thermal profile and its use in tumor functional state estimation

Michal Tepper, Asaf Shoval, Israel Gannot

Research output: Contribution to journalArticlepeer-review

Abstract

Thermal differences between transplanted tumors and tumors in humans prevent the implementation of thermographic methods developed in mice models to human models and vise-versa. Transplantable tumors tend to have an extruding shape, which may affect the thermal patterns. This hypothesis was studied in phantom experiments and simulations. A correlation between tumor dimensions and relative temperature was found and used to estimate tumor functional state from previously published in vivo experiments. A correlation was found between temperature differences and tumor growth rates (tumor aggressiveness) and the effect of tumor treatment was demonstrated, showing the potential for in vivo, non-invasive tumor monitoring.

Original languageEnglish (US)
Pages (from-to)258-264
Number of pages7
JournalJournal of biophotonics
Volume8
Issue number3
DOIs
StatePublished - Mar 1 2015

Keywords

  • Cancer
  • Temperature mapping
  • Tumor thermometry
  • Xenografts

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Science(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Engineering(all)
  • Physics and Astronomy(all)

Fingerprint Dive into the research topics of 'The effect of geometry on tumor thermal profile and its use in tumor functional state estimation'. Together they form a unique fingerprint.

Cite this