Abstract
We investigated the effects of frequency of hemodialysis on nutritional status by analyzing the data in the Frequent Hemodialysis Network Trial. We compared changes in albumin, body weight, and composition among 245 patients randomized to six or three times per week in-center hemodialysis (Daily Trial) and 87 patients randomized to six times per week nocturnal or three times per week conventional hemodialysis, performed largely at home (Nocturnal Trial). In the Daily Trial, there were no significant differences between groups in changes in serum albumin or the equilibrated protein catabolic rate by 12 months. There was a significant relative decrease in predialysis body weight of 1.5±0.2 kg in the six times per week group at 1 month, but this significantly rebounded by 1.3±0.5 kg over the remaining 11 months. Extracellular water (ECW) decreased in the six times per week compared with the three per week hemodialysis group. There were no significant between-group differences in phase angle, intracellular water, or body cell mass (BCM). In the Nocturnal Trial, there were no significant between-group differences in any study parameter. Any gain in 'dry' body weight corresponded to increased adiposity rather than muscle mass but was not statistically significant. Thus, frequent in-center hemodialysis reduced ECW but did not increase serum albumin or BCM while frequent nocturnal hemodialysis yielded no net effect on parameters of nutritional status or body composition.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 90-99 |
| Number of pages | 10 |
| Journal | Kidney international |
| Volume | 82 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jul 1 2012 |
| Externally published | Yes |
Keywords
- chronic hemodialysis
- daily hemodialysis
- hypoalbuminemia
- nutrition
- randomized controlled trials
ASJC Scopus subject areas
- Nephrology
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The effect of frequent hemodialysis on nutrition and body composition : Frequent Hemodialysis Network Trial. / Kaysen, George A.; Greene, Tom; Larive, Brett; Mehta, Ravindra L.; Lindsay, Robert M.; Depner, Tom A.; Hall, Yoshio N.; Daugirdas, John T.; Chertow, Glenn M.; Achinger, S.; Anderson, S.; Appel, L.; Apruzzes, R.; Atwal, J.; Augustine, B.; Ayus, J.; Bardsley, J.; Bay, W.; Beach, S.; Beck, G.; Bharti, B.; Briggs, J.; Bullas, R.; Burkart, J.; Burrowes, J.; Cabezon, E.; Callegari, J.; Carter, M.; Champagne, J.; Chan, C.; Chan, W.; Chang, J.; Cheung, A.; Copland, M.; Coplon, N.; Coppley, A.; Dellagrottaglie, S.; Derse, A.; Dominguez, A.; Doss, S.; Eggers, P.; Eknoyan, G.; Escalada, R.; Fensterer, A.; Finkelstein, F.; Fofie, Y.; Franzwa, B.; Frome, R.; Fu, Z.; Garg, A.; Gassman, J.; Gayda, P.; Geller, N.; Geronemus, R.; Goodman, W.; Gorodetskaya, I.; Gotch, F.; Greenwood, R.; Grimm, R.; Gutierrez, M.; Handelman, G.; Henderson, L.; Hernandez, A.; Higgins, H.; Hilkin, A.; Hostetter, T.; Hoy, C.; Humphreys, M.; Hunsicker, L.; James, S.; Kariisa, M.; Kaufman, A.; Kaufman, T.; Ke, S.; Keene, R.; Kimmel, P.; Kliger, A.; Kotanko, P.; Kramer, C.; Kuhlmann, M.; Kwan, S.; Kwok, S.; Lacson, E.; Leavell, E.; Lemus, D.; Levin, A.; Levin, N.; Li, M.; Lilli, K.; Lockridge, R.; Luan, J.; MacKrell, J.; Manaster, R.; Mandaci, O.; Mathew, R.; Mauck, V.; Mazzorato, A.; McCulloch, C.; McGrath-Chong, M.; McLeroy, S.; Meisels, I.; Miller, B.; Mohr, P.; Moossavi, S.; Nabali, A.; Narva, A.; Nissenson, A.; Ornt, D.; Painter, P.; Pepas, J.; Peterson, C.; Pierratos, A.; Pipkin, M.; Prichard, S.; Rajagopalan, S.; Ramos, R.; Rashid, M.; Rastogi, A.; Regozo, K.; Riley, J.; Rivas, M.; Rocco, M.; Rodriquez, R.; Roecker, E.; Roger, D.; Rogers, J.; Salusky, I.; Sanz, G.; Sanz, J.; Schiller-Moran, B.; Schlarb, J.; Schuessler, R.; Schulman, G.; Schweitzer, S.; Sergeyeva, O.; Shah, S.; Sherer, S.; Sika, M.; Sioson, L.; Skelton, R.; Smith, M.; Snell, C.; Somers, D.; Sonico, J.; Spanner, E.; Star, R.; Steigerwald, D.; Stokes, J.; Suri, R.; Suter, M.; Tamura, M.; Tarallo, M.; Tichy, M.; Ting, G.; Tran, T.; Ulloa, D.; Unruh, M.; Vassalotti, J.; Wallace, W.; Waterman, E.; Wei, J.; Weiss, B.; West, J.; Wiggins, K.; Winchester, J.
In: Kidney international, Vol. 82, No. 1, 01.07.2012, p. 90-99.Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - The effect of frequent hemodialysis on nutrition and body composition
T2 - Frequent Hemodialysis Network Trial
AU - Kaysen, George A.
AU - Greene, Tom
AU - Larive, Brett
AU - Mehta, Ravindra L.
AU - Lindsay, Robert M.
AU - Depner, Tom A.
AU - Hall, Yoshio N.
AU - Daugirdas, John T.
AU - Chertow, Glenn M.
AU - Achinger, S.
AU - Anderson, S.
AU - Appel, L.
AU - Apruzzes, R.
AU - Atwal, J.
AU - Augustine, B.
AU - Ayus, J.
AU - Bardsley, J.
AU - Bay, W.
AU - Beach, S.
AU - Beck, G.
AU - Bharti, B.
AU - Briggs, J.
AU - Bullas, R.
AU - Burkart, J.
AU - Burrowes, J.
AU - Cabezon, E.
AU - Callegari, J.
AU - Carter, M.
AU - Champagne, J.
AU - Chan, C.
AU - Chan, W.
AU - Chang, J.
AU - Cheung, A.
AU - Copland, M.
AU - Coplon, N.
AU - Coppley, A.
AU - Dellagrottaglie, S.
AU - Derse, A.
AU - Dominguez, A.
AU - Doss, S.
AU - Eggers, P.
AU - Eknoyan, G.
AU - Escalada, R.
AU - Fensterer, A.
AU - Finkelstein, F.
AU - Fofie, Y.
AU - Franzwa, B.
AU - Frome, R.
AU - Fu, Z.
AU - Garg, A.
AU - Gassman, J.
AU - Gayda, P.
AU - Geller, N.
AU - Geronemus, R.
AU - Goodman, W.
AU - Gorodetskaya, I.
AU - Gotch, F.
AU - Greenwood, R.
AU - Grimm, R.
AU - Gutierrez, M.
AU - Handelman, G.
AU - Henderson, L.
AU - Hernandez, A.
AU - Higgins, H.
AU - Hilkin, A.
AU - Hostetter, T.
AU - Hoy, C.
AU - Humphreys, M.
AU - Hunsicker, L.
AU - James, S.
AU - Kariisa, M.
AU - Kaufman, A.
AU - Kaufman, T.
AU - Ke, S.
AU - Keene, R.
AU - Kimmel, P.
AU - Kliger, A.
AU - Kotanko, P.
AU - Kramer, C.
AU - Kuhlmann, M.
AU - Kwan, S.
AU - Kwok, S.
AU - Lacson, E.
AU - Leavell, E.
AU - Lemus, D.
AU - Levin, A.
AU - Levin, N.
AU - Li, M.
AU - Lilli, K.
AU - Lockridge, R.
AU - Luan, J.
AU - MacKrell, J.
AU - Manaster, R.
AU - Mandaci, O.
AU - Mathew, R.
AU - Mauck, V.
AU - Mazzorato, A.
AU - McCulloch, C.
AU - McGrath-Chong, M.
AU - McLeroy, S.
AU - Meisels, I.
AU - Miller, B.
AU - Mohr, P.
AU - Moossavi, S.
AU - Nabali, A.
AU - Narva, A.
AU - Nissenson, A.
AU - Ornt, D.
AU - Painter, P.
AU - Pepas, J.
AU - Peterson, C.
AU - Pierratos, A.
AU - Pipkin, M.
AU - Prichard, S.
AU - Rajagopalan, S.
AU - Ramos, R.
AU - Rashid, M.
AU - Rastogi, A.
AU - Regozo, K.
AU - Riley, J.
AU - Rivas, M.
AU - Rocco, M.
AU - Rodriquez, R.
AU - Roecker, E.
AU - Roger, D.
AU - Rogers, J.
AU - Salusky, I.
AU - Sanz, G.
AU - Sanz, J.
AU - Schiller-Moran, B.
AU - Schlarb, J.
AU - Schuessler, R.
AU - Schulman, G.
AU - Schweitzer, S.
AU - Sergeyeva, O.
AU - Shah, S.
AU - Sherer, S.
AU - Sika, M.
AU - Sioson, L.
AU - Skelton, R.
AU - Smith, M.
AU - Snell, C.
AU - Somers, D.
AU - Sonico, J.
AU - Spanner, E.
AU - Star, R.
AU - Steigerwald, D.
AU - Stokes, J.
AU - Suri, R.
AU - Suter, M.
AU - Tamura, M.
AU - Tarallo, M.
AU - Tichy, M.
AU - Ting, G.
AU - Tran, T.
AU - Ulloa, D.
AU - Unruh, M.
AU - Vassalotti, J.
AU - Wallace, W.
AU - Waterman, E.
AU - Wei, J.
AU - Weiss, B.
AU - West, J.
AU - Wiggins, K.
AU - Winchester, J.
N1 - Funding Information: Members of the FHN Trial Group are Achinger S, Anderson S, Appel L, Apruzzes R, Atwal J, Augustine B, Ayus J, Bardsley J, Bay W, Beach S, Beck G, Bharti B, Briggs J, Bullas R, Burkart J, Burrowes J, Cabezon E, Callegari J, Carter M, Champagne J, Chan C, Chan W, Chang J, Chertow G, Cheung A, Copland M, Coplon N, Coppley A, Daugirdas J, Dellagrottaglie S, Depner T, Derse A, Dominguez A, Doss S, Eggers P, Eknoyan G, Escalada R, Fensterer A, Finkelstein F, Fofie Y, Franzwa B, Frome R, Fu Z, Garg A, Gassman J, Gayda P, Geller N, Geronemus R, Goodman W, Gorodetskaya I, Gotch F, Greene T, Greenwood R, Grimm R, Gutierrez M, Hall Y, Handelman G, Henderson L, Hernandez A, Higgins H, Hilkin A, Hostetter T, Hoy C, Humphreys M, Hunsicker L, James S, Kariisa M, Kaufman A, Kaufman T, Kaysen G, Ke S, Keene R, Kimmel P, Kliger A, Kotanko P, Kramer C, Kuhlmann M, Kwan S, Kwok S, Lacson E, Larive B, Leavell E, Lemus D, Levin A, Levin N, Li M, Lilli K, Lindsay R, Lockridge R, Luan J, MacKrell J, Manaster R, Mandaci O, Mathew R, Mauck V, Mazzorato A, McCulloch C, McGrath-Chong M, McLeroy S, Mehta R, Meisels I, Miller B, Mohr P, Moossavi S, Nabali A, Narva A, Nissenson A, Ornt D, Painter P, Pepas J, Peterson C, Pierratos A, Pipkin M, Prichard S, Rajagopalan S, Ramos R, Rashid M, Rastogi A, Regozo K, Riley J, Rivas M, Rocco M, Rodriquez R, Roecker E, Roger D, Rogers J, Salusky I, Sanz G, Sanz J, Schiller-Moran B, Schlarb J, Schuessler R, Schulman G, Schweitzer S, Sergeyeva O, Shah S, Sherer S, Sika M, Sioson L, Skelton R, Smith M, Snell C, Somers D, Sonico J, Spanner E, Star R, Steigerwald D, Stokes J, Suri R, Suter M, Tamura M, Tarallo M, Tichy M, Ting G, Tran T, Ulloa D, Unruh M, Vassalotti J, Wallace W, Waterman E, Wei J, Weiss B, West J, Wiggins K, and Winchester J. The FHN Trials were supported by the National Institutes of Health (NIH), National Institutes of Diabetes and Digestive and Kidney Diseases, the Centers for Medicare and Medicaid Services, and the NIH Research Foundation. Contributors to the NIH Foundation in support of the FHN Trials included Amgen, Baxter, and Dialysis Clinics. Additional support was provided by DaVita, Dialysis Clinics, Fresenius Medical Care, Renal Advantage, Renal Research Institute, and Satellite Healthcare.
PY - 2012/7/1
Y1 - 2012/7/1
N2 - We investigated the effects of frequency of hemodialysis on nutritional status by analyzing the data in the Frequent Hemodialysis Network Trial. We compared changes in albumin, body weight, and composition among 245 patients randomized to six or three times per week in-center hemodialysis (Daily Trial) and 87 patients randomized to six times per week nocturnal or three times per week conventional hemodialysis, performed largely at home (Nocturnal Trial). In the Daily Trial, there were no significant differences between groups in changes in serum albumin or the equilibrated protein catabolic rate by 12 months. There was a significant relative decrease in predialysis body weight of 1.5±0.2 kg in the six times per week group at 1 month, but this significantly rebounded by 1.3±0.5 kg over the remaining 11 months. Extracellular water (ECW) decreased in the six times per week compared with the three per week hemodialysis group. There were no significant between-group differences in phase angle, intracellular water, or body cell mass (BCM). In the Nocturnal Trial, there were no significant between-group differences in any study parameter. Any gain in 'dry' body weight corresponded to increased adiposity rather than muscle mass but was not statistically significant. Thus, frequent in-center hemodialysis reduced ECW but did not increase serum albumin or BCM while frequent nocturnal hemodialysis yielded no net effect on parameters of nutritional status or body composition.
AB - We investigated the effects of frequency of hemodialysis on nutritional status by analyzing the data in the Frequent Hemodialysis Network Trial. We compared changes in albumin, body weight, and composition among 245 patients randomized to six or three times per week in-center hemodialysis (Daily Trial) and 87 patients randomized to six times per week nocturnal or three times per week conventional hemodialysis, performed largely at home (Nocturnal Trial). In the Daily Trial, there were no significant differences between groups in changes in serum albumin or the equilibrated protein catabolic rate by 12 months. There was a significant relative decrease in predialysis body weight of 1.5±0.2 kg in the six times per week group at 1 month, but this significantly rebounded by 1.3±0.5 kg over the remaining 11 months. Extracellular water (ECW) decreased in the six times per week compared with the three per week hemodialysis group. There were no significant between-group differences in phase angle, intracellular water, or body cell mass (BCM). In the Nocturnal Trial, there were no significant between-group differences in any study parameter. Any gain in 'dry' body weight corresponded to increased adiposity rather than muscle mass but was not statistically significant. Thus, frequent in-center hemodialysis reduced ECW but did not increase serum albumin or BCM while frequent nocturnal hemodialysis yielded no net effect on parameters of nutritional status or body composition.
KW - chronic hemodialysis
KW - daily hemodialysis
KW - hypoalbuminemia
KW - nutrition
KW - randomized controlled trials
UR - http://www.scopus.com/inward/record.url?scp=84862494377&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84862494377&partnerID=8YFLogxK
U2 - 10.1038/ki.2012.75
DO - 10.1038/ki.2012.75
M3 - Article
C2 - 22456602
AN - SCOPUS:84862494377
VL - 82
SP - 90
EP - 99
JO - Kidney International
JF - Kidney International
SN - 0085-2538
IS - 1
ER -