The effect of exchange transfusion on endogenous carbon monoxide production in erythroblastotic infants

M. Jeffrey Maisels, Ambadas Pathak, Nicholas M. Nelson

Research output: Contribution to journalArticle

Abstract

In order to elucidate the mechanism of the "late" postexchange transfusion bilirubin rebound, we measured endogenous carbon monoxide production in infants with erythroblastosis fetalis before and after exchange transfusions. The rate of carbon monoxide production was markedly increased before the first exchange transfusion and remained elevated until two, or in one case until three, exchange transfusions had been completed. Normal rates of carbon monoxide production were found when falling levels of serum bilirubin concentration indicated that further exchange transfusions were not necessary. These findings suggest that a continued increase in heme turnover is largely responsible for the "late" bilirubin rebound which occurs after exchange transfusions.

Original languageEnglish (US)
Pages (from-to)705-709
Number of pages5
JournalThe Journal of pediatrics
Volume81
Issue number4
DOIs
StatePublished - Oct 1972
Externally publishedYes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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