TY - JOUR
T1 - The effect of diisopropyl fluorophosphonate on the sensitivity of rats to centrally acting drugs
AU - BAYLISS, B. J.
AU - ELKES, J.
AU - SPANNER, S. G.
AU - TODRICK, A.
PY - 1957/12/1
Y1 - 1957/12/1
N2 - The effect of a previous injection of an anticholinesterase, dyflos, on the sensitivity of rats to two centrally acting drugs, pentobarbitone and leptazol, has been measured. The sensitivity was determined at 12 and 35 days after birth and in full-grown animals. Though the dose of dyflos was of the order of two-thirds of the LD50, it did not affect the sensitivity of the young animals to sodium pentobarbitone and leptazol administered 20 hours later. The full-grown animals which had received dyflos in arachis oil were more sensitive to sodium pentobarbitone than litter mates which had received an injection of arachis oil only; this difference was significant at the 0.1% level. The dyflos treatment did not significantly affect the sensitivity to leptazol.
AB - The effect of a previous injection of an anticholinesterase, dyflos, on the sensitivity of rats to two centrally acting drugs, pentobarbitone and leptazol, has been measured. The sensitivity was determined at 12 and 35 days after birth and in full-grown animals. Though the dose of dyflos was of the order of two-thirds of the LD50, it did not affect the sensitivity of the young animals to sodium pentobarbitone and leptazol administered 20 hours later. The full-grown animals which had received dyflos in arachis oil were more sensitive to sodium pentobarbitone than litter mates which had received an injection of arachis oil only; this difference was significant at the 0.1% level. The dyflos treatment did not significantly affect the sensitivity to leptazol.
KW - ISOFLUROPHATE/effects
KW - PENTOBARBITAL/effects
KW - PENTYLENETETRAZOLE/effects
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U2 - 10.1111/j.1476-5381.1957.tb00179.x
DO - 10.1111/j.1476-5381.1957.tb00179.x
M3 - Article
C2 - 13489188
AN - SCOPUS:84961021892
SN - 0366-0826
VL - 12
SP - 536
EP - 539
JO - British Journal of Pharmacology and Chemotherapy
JF - British Journal of Pharmacology and Chemotherapy
IS - 4
ER -