The effect of diisopropyl fluorophosphonate on the sensitivity of rats to centrally acting drugs

B. J. BAYLISS, J. ELKES, S. G. SPANNER, A. TODRICK

Research output: Contribution to journalArticlepeer-review

Abstract

The effect of a previous injection of an anticholinesterase, dyflos, on the sensitivity of rats to two centrally acting drugs, pentobarbitone and leptazol, has been measured. The sensitivity was determined at 12 and 35 days after birth and in full-grown animals. Though the dose of dyflos was of the order of two-thirds of the LD50, it did not affect the sensitivity of the young animals to sodium pentobarbitone and leptazol administered 20 hours later. The full-grown animals which had received dyflos in arachis oil were more sensitive to sodium pentobarbitone than litter mates which had received an injection of arachis oil only; this difference was significant at the 0.1% level. The dyflos treatment did not significantly affect the sensitivity to leptazol.

Original languageEnglish (US)
Pages (from-to)536-539
Number of pages4
JournalBritish Journal of Pharmacology and Chemotherapy
Volume12
Issue number4
DOIs
StatePublished - Dec 1 1957

Keywords

  • ISOFLUROPHATE/effects
  • PENTOBARBITAL/effects
  • PENTYLENETETRAZOLE/effects

ASJC Scopus subject areas

  • Medicine(all)

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