The effect of cyclic AMP on glycogenolysis and glycolysis in human platelets

Philip D. Zieve, Morton Schmukler

Research output: Contribution to journalArticle


Cyclic AMP increased glycogenolysis and stimulated phosphorylase in sonicates of human platelets. Paradoxically, lactate formation formation was reduced by cyclic AMP in platelet lysates as well as by dibutyryl cyclic AMP and prostaglandin E1. This decrease in lactate formation appears to be mediated by an inhibition of phosphofructokinase. These metabolic effects of cyclic AMP may be related to the inhibition of aggregation of platelets by this compound and by agents which stimulate its production.

Original languageEnglish (US)
Pages (from-to)280-284
Number of pages5
JournalBBA - General Subjects
Issue number2
StatePublished - Nov 12 1971


ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology

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