TY - JOUR
T1 - The effect of cyclic AMP on glycogenolysis and glycolysis in human platelets
AU - Zieve, Philip D.
AU - Schmukler, Morton
N1 - Funding Information:
grant, HE-o9Io2, from the National Heart
Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1971/11/12
Y1 - 1971/11/12
N2 - Cyclic AMP increased glycogenolysis and stimulated phosphorylase in sonicates of human platelets. Paradoxically, lactate formation formation was reduced by cyclic AMP in platelet lysates as well as by dibutyryl cyclic AMP and prostaglandin E1. This decrease in lactate formation appears to be mediated by an inhibition of phosphofructokinase. These metabolic effects of cyclic AMP may be related to the inhibition of aggregation of platelets by this compound and by agents which stimulate its production.
AB - Cyclic AMP increased glycogenolysis and stimulated phosphorylase in sonicates of human platelets. Paradoxically, lactate formation formation was reduced by cyclic AMP in platelet lysates as well as by dibutyryl cyclic AMP and prostaglandin E1. This decrease in lactate formation appears to be mediated by an inhibition of phosphofructokinase. These metabolic effects of cyclic AMP may be related to the inhibition of aggregation of platelets by this compound and by agents which stimulate its production.
UR - http://www.scopus.com/inward/record.url?scp=0015221279&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0015221279&partnerID=8YFLogxK
U2 - 10.1016/0304-4165(71)90008-0
DO - 10.1016/0304-4165(71)90008-0
M3 - Article
C2 - 4332298
AN - SCOPUS:0015221279
VL - 252
SP - 280
EP - 284
JO - Biochimica et Biophysica Acta - General Subjects
JF - Biochimica et Biophysica Acta - General Subjects
SN - 0304-4165
IS - 2
ER -