Cyclic AMP increased glycogenolysis and stimulated phosphorylase in sonicates of human platelets. Paradoxically, lactate formation formation was reduced by cyclic AMP in platelet lysates as well as by dibutyryl cyclic AMP and prostaglandin E1. This decrease in lactate formation appears to be mediated by an inhibition of phosphofructokinase. These metabolic effects of cyclic AMP may be related to the inhibition of aggregation of platelets by this compound and by agents which stimulate its production.
ASJC Scopus subject areas
- Molecular Biology