The effect of cyclic AMP on glycogenolysis and glycolysis in human platelets

Philip D. Zieve; Morton Schmukler

doi:10.1016/0304-4165(71)90008-0

The effect of cyclic AMP on glycogenolysis and glycolysis in human platelets

Philip D. Zieve, Morton Schmukler

School of Medicine

Research output: Contribution to journal › Article

Abstract

Cyclic AMP increased glycogenolysis and stimulated phosphorylase in sonicates of human platelets. Paradoxically, lactate formation formation was reduced by cyclic AMP in platelet lysates as well as by dibutyryl cyclic AMP and prostaglandin E₁. This decrease in lactate formation appears to be mediated by an inhibition of phosphofructokinase. These metabolic effects of cyclic AMP may be related to the inhibition of aggregation of platelets by this compound and by agents which stimulate its production.

Original language	English (US)
Pages (from-to)	280-284
Number of pages	5
Journal	BBA - General Subjects
Volume	252
Issue number	2
DOIs	https://doi.org/10.1016/0304-4165(71)90008-0
State	Published - Nov 12 1971

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ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology

Cite this

Zieve, P. D., & Schmukler, M. (1971). The effect of cyclic AMP on glycogenolysis and glycolysis in human platelets. BBA - General Subjects, 252(2), 280-284. https://doi.org/10.1016/0304-4165(71)90008-0

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Access to Document

10.1016/0304-4165(71)90008-0