The effect of corticosteroids, dapsone and gold upon plasminogen activator synthesis and secretion by human epidermal cells cultured with pemphigus antibody

K. HASHIMOTO, KAY SINGER, G. S. LAZARUS

Research output: Contribution to journalArticlepeer-review

Abstract

Human epidermal cells were cultured with pemphigus antibody in the presence of hydrocortisone, methlprednisolone sodium succinate, dapsone and gold. Hydrocortisone and methylprednisolone reduced the production of the enzyme plasminogen activator but dapsone and gold had no effect. These results support the hypothesis that corticosteroids have dual effects on pemphigus through inhibition of plasminogen activator production by epidermal cells and suppression of pemphigus antibody production by B lymphocytes.

Original languageEnglish (US)
Pages (from-to)293-297
Number of pages5
JournalBritish Journal of Dermatology
Volume110
Issue number3
DOIs
StatePublished - Mar 1984
Externally publishedYes

ASJC Scopus subject areas

  • Dermatology

Fingerprint Dive into the research topics of 'The effect of corticosteroids, dapsone and gold upon plasminogen activator synthesis and secretion by human epidermal cells cultured with pemphigus antibody'. Together they form a unique fingerprint.

Cite this