The course of Sindbis virus infection in 12-day-old BALB/c mice was altered significantly in animals depleted of the third component of complement (C3) by treatment with purified cobra venom (CoVF). Although the same percentage of C3-depleted and normal animals died (30%) after the subcutaneous inoculation of 1000 PFU Sindbis virus, the mean day of death was later in C3-depleted mice (8.4 days) than in controls (6.5 days). In addition, morbidity was prolonged in C3-depleted mice. Growth of virus at the inoculation site in the foot was not different; however, viremia was prolonged and the amount of virus in the brain was 1000-fold greater 6 days after infection in C3-depleted animals. These studies demonstrated that complement plays an important role in the host's response to Sindbis virus infection by participating in both beneficial and immunopathologic responses to the infection.
|Original language||English (US)|
|Number of pages||3|
|Journal||Journal of Immunology|
|Publication status||Published - 1978|
The effect of complement depletion on the course of Sindbis virus infection in mice. / Hirsch, R. L.; Griffin, Diane; Winkelstein, J. A.In: Journal of Immunology, Vol. 121, No. 4, 1978, p. 1276-1278.
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