The effect of cold exposure on diffusing capacity in patients with Raynaud's phenomenon

R. A. Wise; F. Wigley; H. H. Newball; M. B. Stevens

doi:10.1378/chest.81.6.695

The effect of cold exposure on diffusing capacity in patients with Raynaud's phenomenon

R. A. Wise, F. Wigley, H. H. Newball, M. B. Stevens

School of Medicine

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

Pulmonary hypertension is common in progressive systemic sclerosis (PSS), and the presence of 'pulmonary Raynaud's phenomenon' has been postulated from a variety of evidence. In this study, the effect of cold-induced Raynaud's phenomenon on carbon monoxide diffusing capacity (DCO), an indicator of pulmonary capillary blood volume, was determined in patients with Raynaud's phenomenon with and without PSS. Cold exposure caused an increase in DCO in patients without PSS, but no change in patients with PSS. We concluded that patients with systemic sclerosis have an altered pulmonary vascular response to cold exposure compared with other Raynaud's patients, which may be due to either structural or functional abnormalities of the pulmonary vascular bed.

Original language	English (US)
Pages (from-to)	695-698
Number of pages	4
Journal	CHEST
Volume	81
Issue number	6
DOIs	https://doi.org/10.1378/chest.81.6.695
State	Published - 1982

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine
Critical Care and Intensive Care Medicine
Cardiology and Cardiovascular Medicine

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title = "The effect of cold exposure on diffusing capacity in patients with Raynaud's phenomenon",

abstract = "Pulmonary hypertension is common in progressive systemic sclerosis (PSS), and the presence of 'pulmonary Raynaud's phenomenon' has been postulated from a variety of evidence. In this study, the effect of cold-induced Raynaud's phenomenon on carbon monoxide diffusing capacity (DCO), an indicator of pulmonary capillary blood volume, was determined in patients with Raynaud's phenomenon with and without PSS. Cold exposure caused an increase in DCO in patients without PSS, but no change in patients with PSS. We concluded that patients with systemic sclerosis have an altered pulmonary vascular response to cold exposure compared with other Raynaud's patients, which may be due to either structural or functional abnormalities of the pulmonary vascular bed.",

author = "Wise, {R. A.} and F. Wigley and Newball, {H. H.} and Stevens, {M. B.}",

note = "Funding Information: The authors gratefully acknowledge the expert technical assistance of Ms. Laurie Wall-bridge and the flawless secretarial assistance of Ms. Joan Tano and Mrs. Barbara Kelley. This work was supported in part by the American Lung Association and the Parker B. Francis Foundation. ",

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AU - Wise, R. A.

AU - Wigley, F.

AU - Newball, H. H.

AU - Stevens, M. B.

N1 - Funding Information: The authors gratefully acknowledge the expert technical assistance of Ms. Laurie Wall-bridge and the flawless secretarial assistance of Ms. Joan Tano and Mrs. Barbara Kelley. This work was supported in part by the American Lung Association and the Parker B. Francis Foundation.

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N2 - Pulmonary hypertension is common in progressive systemic sclerosis (PSS), and the presence of 'pulmonary Raynaud's phenomenon' has been postulated from a variety of evidence. In this study, the effect of cold-induced Raynaud's phenomenon on carbon monoxide diffusing capacity (DCO), an indicator of pulmonary capillary blood volume, was determined in patients with Raynaud's phenomenon with and without PSS. Cold exposure caused an increase in DCO in patients without PSS, but no change in patients with PSS. We concluded that patients with systemic sclerosis have an altered pulmonary vascular response to cold exposure compared with other Raynaud's patients, which may be due to either structural or functional abnormalities of the pulmonary vascular bed.

AB - Pulmonary hypertension is common in progressive systemic sclerosis (PSS), and the presence of 'pulmonary Raynaud's phenomenon' has been postulated from a variety of evidence. In this study, the effect of cold-induced Raynaud's phenomenon on carbon monoxide diffusing capacity (DCO), an indicator of pulmonary capillary blood volume, was determined in patients with Raynaud's phenomenon with and without PSS. Cold exposure caused an increase in DCO in patients without PSS, but no change in patients with PSS. We concluded that patients with systemic sclerosis have an altered pulmonary vascular response to cold exposure compared with other Raynaud's patients, which may be due to either structural or functional abnormalities of the pulmonary vascular bed.

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The effect of cold exposure on diffusing capacity in patients with Raynaud's phenomenon

Abstract

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