The effect of cold exposure on diffusing capacity in patients with Raynaud's phenomenon

Robert A Wise, Fredrick Wigley, H. H. Newball, M. B. Stevens

Research output: Contribution to journalArticle

Abstract

Pulmonary hypertension is common in progressive systemic sclerosis (PSS), and the presence of 'pulmonary Raynaud's phenomenon' has been postulated from a variety of evidence. In this study, the effect of cold-induced Raynaud's phenomenon on carbon monoxide diffusing capacity (DCO), an indicator of pulmonary capillary blood volume, was determined in patients with Raynaud's phenomenon with and without PSS. Cold exposure caused an increase in DCO in patients without PSS, but no change in patients with PSS. We concluded that patients with systemic sclerosis have an altered pulmonary vascular response to cold exposure compared with other Raynaud's patients, which may be due to either structural or functional abnormalities of the pulmonary vascular bed.

Original languageEnglish (US)
Pages (from-to)695-698
Number of pages4
JournalChest
Volume81
Issue number6
StatePublished - 1982

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Raynaud Disease
Diffuse Scleroderma
Lung
Blood Vessels
Systemic Scleroderma
Carbon Monoxide
Blood Volume
Pulmonary Hypertension

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

The effect of cold exposure on diffusing capacity in patients with Raynaud's phenomenon. / Wise, Robert A; Wigley, Fredrick; Newball, H. H.; Stevens, M. B.

In: Chest, Vol. 81, No. 6, 1982, p. 695-698.

Research output: Contribution to journalArticle

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