The effect of cold atmospheric plasma treatment on cancer stem cells

Barry Trink, Michael Keidar, Jerome Canady, Yeela Shamai, Maty Tzukerman

Research output: Contribution to journalArticle

Abstract

Intratumoral heterogeneity challenges existing paradigms for anticancer therapy. Accumulating evidence demonstrates that the model of cancer stem cells (CSCs) and the model of clonal evolution mutually contribute to intratumoral heterogeneity, as CSCs themselves undergo clonal evolution. The limitation of conventional anticancer therapies may lead to treatment failure and cancer recurrence, mainly due to drug resistance and self-renewal capacities of CSC. These two factors are responsible for resistance to standard oncology treatments. In this study, we examine cold atmospheric plasma (CAP) treatment of CSC in vitro. We demonstrate that two types of heterogeneous CSC populations derived from a single patient tumor are sensitive to the effects of plasma treatment. Surprisingly, the more aggressive CSC population (C13) was more sensitive to CAP treatment than the less aggressive type (C12).

Original languageEnglish (US)
Pages (from-to)17-26
Number of pages10
JournalPlasma Medicine
Volume5
Issue number1
DOIs
StatePublished - Jan 1 2015

Keywords

  • CAP treatment in cancer
  • Heterogeneity of cancer stem cells
  • Ovarian cancer
  • Ovarian cancer stem cells

ASJC Scopus subject areas

  • Biomedical Engineering
  • Physics and Astronomy(all)

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  • Cite this

    Trink, B., Keidar, M., Canady, J., Shamai, Y., & Tzukerman, M. (2015). The effect of cold atmospheric plasma treatment on cancer stem cells. Plasma Medicine, 5(1), 17-26. https://doi.org/10.1615/PlasmaMed.v5.i1.20