The effect of cardiovascular and osteoarticular diseases on disability in older Italian men and women: Rationale, design, and sample characteristics of the Progetto Veneto Anziani (PRO.V.A.) Study

Maria Chiara Corti, Jack M. Guralnik, Leonardo Sartori, Giovannella Baggio, Enzo Manzato, Patrizio Pezzotti, Gianmaria Barbato, Sabina Zambon, Luigi Ferrucci, Sergio Minervini, Estella Musacchio, Gaetano Crepaldi

Research output: Contribution to journalArticle

Abstract

OBJECTIVES: Describe the methodology and preliminary results of the Progetto Veneto Anziani (PRO.V.A.) Study, an observational study of the Italian population aged 65 and older DESIGN: Cross-sectional cohort observation. SETTING: Northern Italy. PARTICIPANTS: Italians aged 65 and older, living in both the community and nursing homes. MEASUREMENTS: At baseline, participants were interviewed at their homes and subsequently examined by nurses and physicians at the two study clinics using an extensive battery of clinical, instrumental, biochemical, and physical performance tests. Hand, knee, hip, and chest x-rays and bone densitometry were performed in 92% of the participants, and 99% of the participants consented to blood drawing and deoxyribonucleic acid analyses. The physician who performed the physical examination determined disease presence based on several components of the interview and examination. A further, comprehensive determination was performed with standardized algorithms using all the information collected on each participant, including hospital records surveillance, standardized x-ray readings, and blood assays. In one of the study sites, a brain magnetic resonance imaging was performed in a subsample of the participants (820 persons). RESULTS: Overall response rate to the baseline clinic visit was 77% for men and 64% for women. Co-presence of at least one cardiovascular disease (CVD) and at least one osteoarticular disease (OAD) was identified in 10%, 22%, and 29% of men and 9%, 24%, and 40% of women aged 65 to 74, 75 to 84, and 85 and older, respectively. Overall, the mean number of coexisting chronic conditions was 1.8 for men and 2.4 for women. CONCLUSIONS: The PRO.V.A. study has the potential to provide an original contribution to clarify the mechanisms whereby diseases cause disability in older men and women; the particular focus on CVD and OADs will make it possible to comprehensively evaluate the development of disability as it relates to these two important conditions.

Original languageEnglish (US)
Pages (from-to)1535-1540
Number of pages6
JournalJournal of the American Geriatrics Society
Volume50
Issue number9
DOIs
StatePublished - Sep 2002
Externally publishedYes

Keywords

  • Aging
  • Arthritis
  • Cardiovascular disease
  • Disability
  • Epidemiology
  • Osteoporosis

ASJC Scopus subject areas

  • Geriatrics and Gerontology

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    Corti, M. C., Guralnik, J. M., Sartori, L., Baggio, G., Manzato, E., Pezzotti, P., Barbato, G., Zambon, S., Ferrucci, L., Minervini, S., Musacchio, E., & Crepaldi, G. (2002). The effect of cardiovascular and osteoarticular diseases on disability in older Italian men and women: Rationale, design, and sample characteristics of the Progetto Veneto Anziani (PRO.V.A.) Study. Journal of the American Geriatrics Society, 50(9), 1535-1540. https://doi.org/10.1046/j.1532-5415.2002.50409.x