The Effect of Cardiopulmonary Bypass Perfusion Pressure on Myocardial Gas Tensions in the Presence of Coronary Stenosis

Shukri F. Khuri, Robert K. Brawley, John B. O'Riordan, James S. Donahoo, Bertram Pitt, Vincent L. Gott

Research output: Contribution to journalArticle

Abstract

Mass spectrometry was utilized to determine myocardial gas tensions in dogs subjected to cardiopulmonary bypass. Myocardial ischemia occurred in animals with normal coronary arteries when cardiopulmonary bypass perfusion pressure fell 40 to 60 mm Hg below the mean aortic pressure measured prior to bypass. Myocardial ischemia did not occur, or could be eliminated when present, if cardiopulmonary bypass perfusion pressure was maintained near prebypass mean aortic pressure. In animals with constricted circumflex coronary arteries, the adverse effect of low perfusion pressure on myocardial metabolism during cardiopulmonary bypass was found to be more severe in areas of myocardium supplied by the stenotic coronary artery. It is concluded that maintenance of cardiopulmonary bypass perfusion pressure near the level of preoperative mean aortic pressure will help prevent myocardial ischemia during operation, particularly in patients with coronary artery disease.

Original languageEnglish (US)
Pages (from-to)661-670
Number of pages10
JournalAnnals of Thoracic Surgery
Volume20
Issue number6
DOIs
StatePublished - Jan 1 1975

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

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