The effect of aquaporin 5 overexpression on the Ras signaling pathway

Janghee Woo, Juna Lee, Myoung Sook Kim, Se Jin Jang, David Sidransky, Chulso Moon

Research output: Contribution to journalArticlepeer-review

Abstract

Human aquaporin 5 (AQP5) has been shown to be overexpressed in multiple cancers, such as pancreatic cancer and colon cancer. Furthermore, it has been reported that ectopic expression of AQP5 leads to many phenotypic changes characteristic of transformation. However, the biochemical mechanism leading to transformation in AQP5-overexpressing cells has not been clearly elucidated. In this report, the overexpression of AQP5 in NIH3T3 cells demonstrated a significant effect on Ras activity and, thus, cell proliferation. Furthermore, this influence was shown to be mediated by phosphorylation of the PKA consensus site of AQP5. This is the first evidence demonstrating an association between AQP5 and a signaling pathway, namely the Ras signal transduction pathway, which may be the basis of the oncogenic properties seen in AQP-overexpressing cells.

Original languageEnglish (US)
Pages (from-to)291-298
Number of pages8
JournalBiochemical and Biophysical Research Communications
Volume367
Issue number2
DOIs
StatePublished - Mar 7 2008

Keywords

  • Aquaporin 5
  • Aquaporins
  • Ras

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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