The effect of antioxidant vitamin supplementation on traditional cardiovascular risk factors

Research output: Contribution to journalArticle

Abstract

Background: Evidence from observational epidemiologic studies has indicated that antioxidants consumed through the diet or as dietary supplements lower the risk of developing atherosclerotic cardiovascular disease. Evidence suggesting that the major mechanism for the protective effect of antioxidants is mediated through decreased oxidation of lipids, particularly low-density lipoprotein (LDL) cholesterol is accumulating. Other evidence, however, suggests that antioxidants may influence traditional modifiable cardiovascular risk factors such as the blood pressure and serum lipids favorably. The purpose of this study was to determine the effect of antioxidant vitamin supplementation on modifiable risk factors for atherosclerotic cardiovascular disease. Design: A randomized, placebo controlled, clinical trial of antioxidant vitamin supplementation, conducted at a single community-based clinical research center. Methods: We assigned 297 retired teachers who were members of the Maryland Retired Teachers Association randomly to 2-4 months of dietary supplementation with placebo or combined antioxidant vitamin capsules providing 400 IU/day vitamin E, 500mg/day vitamin C, and 6 mg/day β-carotene. The outcome measures were the blood pressure, fasting serum total cholesterol, high-density lipoprotein cholesterol, LDL cholesterol, and fasting glucose. Results: After 2-4 months of supplementation the combined antioxidant supplement had had no significant effect on the systolic and diastolic blood pressures, fasting serum lipids (total cholesterol, high-density lipoprotein cholesterol, and LDL cholesterol) and fasting glucose, with unadjusted and adjusted analyses. Conclusion: Data from this trial suggest that the protective effect from antioxidant vitamin supplementation, if there is one, likely results from mechanisms other than modification of traditionally modifiable cardiovascular risk factors.

Original languageEnglish (US)
Pages (from-to)19-24
Number of pages6
JournalJournal of Cardiovascular Risk
Volume4
Issue number1
StatePublished - 1997

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Vitamins
Antioxidants
Fasting
LDL Cholesterol
Blood Pressure
Dietary Supplements
Lipids
HDL Cholesterol
Cardiovascular Diseases
Serum
Cholesterol
Placebos
Glucose
Carotenoids
Vitamin E
Ascorbic Acid
Capsules
Observational Studies
Epidemiologic Studies
Randomized Controlled Trials

Keywords

  • Antioxidant vitamins
  • Atherosclerotic cardiovascular disease
  • Blood pressure
  • Serum glucose
  • Serum lipids

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

The effect of antioxidant vitamin supplementation on traditional cardiovascular risk factors. / Miller, Edgar R; Appel, Lawrence; Levander, Orville A.; Levine, David.

In: Journal of Cardiovascular Risk, Vol. 4, No. 1, 1997, p. 19-24.

Research output: Contribution to journalArticle

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