TY - JOUR
T1 - [The effect of anesthetic concentration on burst-suppression of the EEG in rats].
AU - Zhang, Dandan
AU - Jia, Xiaofeng
AU - Ding, Haiyan
N1 - Copyright:
This record is sourced from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
PY - 2012/4
Y1 - 2012/4
N2 - The term "burst-suppression" is used to describe the electroencephalogram (EEG) pattern characterized by theta or delta waves, at times intermixed with faster waves, and intervening periods of relative quiescence. Burst-suppression pattern can reflect the seriously suppressed brain activity under deep anesthesia. To investigate the relationship between burst-suppression features and anesthetic concentration, we adopted four straightforward indexes, i. e., burst-suppression ratio (BSR), burst frequency, burst amplitude and suppression amplitude, and used them to analyze the EEG recordings in ten isoflurane-anesthetized rats. It was found that all the four burst-suppression indexes changed along with anesthetic concentration, that BSR and burst amplitude increased with higher concentration of isoflurane while burst frequency and suppression amplitude decreased, and that BSR was the most sensitive and consistent measurement to indicate isoflurane concentration so it constituted a valuable tool for timely evaluation of burst-suppression feature under deep anesthesia. The result also showed that the composition of carrier gas (i. e. pure oxygen vs. mixed oxygen) did not influence the effect of anesthesia significantly; and the four indexes of burst-suppression features could keep relatively stable within 60 min under the isoflurane concentration of 2%. The present study provides quantitative information of burst-suppression features under different anesthetic depth and may help to develop a clinically satisfied system that could quantify the characteristics of EEG and rigorously evaluate the cerebral state of patients.
AB - The term "burst-suppression" is used to describe the electroencephalogram (EEG) pattern characterized by theta or delta waves, at times intermixed with faster waves, and intervening periods of relative quiescence. Burst-suppression pattern can reflect the seriously suppressed brain activity under deep anesthesia. To investigate the relationship between burst-suppression features and anesthetic concentration, we adopted four straightforward indexes, i. e., burst-suppression ratio (BSR), burst frequency, burst amplitude and suppression amplitude, and used them to analyze the EEG recordings in ten isoflurane-anesthetized rats. It was found that all the four burst-suppression indexes changed along with anesthetic concentration, that BSR and burst amplitude increased with higher concentration of isoflurane while burst frequency and suppression amplitude decreased, and that BSR was the most sensitive and consistent measurement to indicate isoflurane concentration so it constituted a valuable tool for timely evaluation of burst-suppression feature under deep anesthesia. The result also showed that the composition of carrier gas (i. e. pure oxygen vs. mixed oxygen) did not influence the effect of anesthesia significantly; and the four indexes of burst-suppression features could keep relatively stable within 60 min under the isoflurane concentration of 2%. The present study provides quantitative information of burst-suppression features under different anesthetic depth and may help to develop a clinically satisfied system that could quantify the characteristics of EEG and rigorously evaluate the cerebral state of patients.
UR - http://www.scopus.com/inward/record.url?scp=84884652925&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84884652925&partnerID=8YFLogxK
M3 - Article
C2 - 22616162
AN - SCOPUS:84884652925
SN - 1001-5515
VL - 29
SP - 223-228, 232
JO - Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi
JF - Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi
IS - 2
ER -