The effect of androgens on lipids

Anne K. Monroe, Adrian S Dobs

Research output: Contribution to journalArticle

Abstract

Purpose of Review: To review recent data concerning the relationship between endogenous testosterone and lipids as well as testosterone replacement therapy and lipids. To describe the effects of sex hormones on cardiovascular disease (CVD) that may act via serum lipids. Recent Findings: Low endogenous testosterone is associated with high low-density lipoprotein and low high-density lipoprotein in both cross-sectional and prospective observational studies. Exogenous testosterone administration is associated with decreased high-density lipoprotein coupled with beneficial decreases in low-density lipoprotein and total cholesterol. The overall impact of testosterone administration on CVD is still unclear, with mixed safety results from recent randomized controlled trials. Summary: There may be CVD risk reduction benefits, including an improved lipid profile, from testosterone administration in hypogonadal men. The overall effect of testosterone on CVD risk has not been definitively determined.

Original languageEnglish (US)
Pages (from-to)132-139
Number of pages8
JournalCurrent Opinion in Endocrinology, Diabetes and Obesity
Volume20
Issue number2
DOIs
StatePublished - Apr 2013

Fingerprint

Androgens
Testosterone
Lipids
Cardiovascular Diseases
HDL Lipoproteins
LDL Lipoproteins
Gonadal Steroid Hormones
Risk Reduction Behavior
LDL Cholesterol
Observational Studies
Randomized Controlled Trials
Prospective Studies
Safety
Serum

Keywords

  • Cardiovascular disease
  • Lipids
  • Testosterone

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine
  • Nutrition and Dietetics

Cite this

The effect of androgens on lipids. / Monroe, Anne K.; Dobs, Adrian S.

In: Current Opinion in Endocrinology, Diabetes and Obesity, Vol. 20, No. 2, 04.2013, p. 132-139.

Research output: Contribution to journalArticle

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