The effect of androgens on lipids

Anne K. Monroe, Adrian S. Dobs

Research output: Contribution to journalReview articlepeer-review

Abstract

Purpose of Review: To review recent data concerning the relationship between endogenous testosterone and lipids as well as testosterone replacement therapy and lipids. To describe the effects of sex hormones on cardiovascular disease (CVD) that may act via serum lipids. Recent Findings: Low endogenous testosterone is associated with high low-density lipoprotein and low high-density lipoprotein in both cross-sectional and prospective observational studies. Exogenous testosterone administration is associated with decreased high-density lipoprotein coupled with beneficial decreases in low-density lipoprotein and total cholesterol. The overall impact of testosterone administration on CVD is still unclear, with mixed safety results from recent randomized controlled trials. Summary: There may be CVD risk reduction benefits, including an improved lipid profile, from testosterone administration in hypogonadal men. The overall effect of testosterone on CVD risk has not been definitively determined.

Original languageEnglish (US)
Pages (from-to)132-139
Number of pages8
JournalCurrent Opinion in Endocrinology, Diabetes and Obesity
Volume20
Issue number2
DOIs
StatePublished - Apr 1 2013

Keywords

  • Cardiovascular disease
  • Lipids
  • Testosterone

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Nutrition and Dietetics

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