The effect of an abuse-deterrent opioid formulation (OxyContin) on opioid abuse-related outcomes in the postmarketing setting

P. M. Coplan; H. D. Chilcoat; S. F. Butler; E. M. Sellers; A. Kadakia; V. Harikrishnan; J. D. Haddox; R. C. Dart

doi:10.1002/cpt.390

The effect of an abuse-deterrent opioid formulation (OxyContin) on opioid abuse-related outcomes in the postmarketing setting

P. M. Coplan, H. D. Chilcoat, S. F. Butler, E. M. Sellers, A. Kadakia, V. Harikrishnan, J. D. Haddox, R. C. Dart

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

52 Scopus citations

Abstract

An extended-release opioid analgesic (OxyContin, OC) was reformulated with abuse-deterrent properties to deter abuse. This report examines changes in abuse through oral and nonoral routes, doctor-shopping, and fatalities in 10 studies 3.5 years after reformulation. Changes in OC abuse from 1 year before to 3 years after OC reformulation were calculated, adjusted for prescription changes. Abuse of OC decreased 48% in national poison center surveillance systems, decreased 32% in a national drug treatment system, and decreased 27% among individuals prescribed OC in claims databases. Doctor-shopping for OC decreased 50%. Overdose fatalities reported to the manufacturer decreased 65%. Abuse of other opioids without abuse-deterrent properties decreased 2 years later than OC and with less magnitude, suggesting OC decreases were not due to broader opioid interventions. Consistent with the formulation, decreases were larger for nonoral than oral abuse. Abuse-deterrent opioids may mitigate abuse and overdose risks among chronic pain patients.

Original language	English (US)
Journal	Clinical Pharmacology and Therapeutics
DOIs	https://doi.org/10.1002/cpt.390
State	Accepted/In press - 2016

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)

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10.1002/cpt.390

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title = "The effect of an abuse-deterrent opioid formulation (OxyContin) on opioid abuse-related outcomes in the postmarketing setting",

abstract = "An extended-release opioid analgesic (OxyContin, OC) was reformulated with abuse-deterrent properties to deter abuse. This report examines changes in abuse through oral and nonoral routes, doctor-shopping, and fatalities in 10 studies 3.5 years after reformulation. Changes in OC abuse from 1 year before to 3 years after OC reformulation were calculated, adjusted for prescription changes. Abuse of OC decreased 48% in national poison center surveillance systems, decreased 32% in a national drug treatment system, and decreased 27% among individuals prescribed OC in claims databases. Doctor-shopping for OC decreased 50%. Overdose fatalities reported to the manufacturer decreased 65%. Abuse of other opioids without abuse-deterrent properties decreased 2 years later than OC and with less magnitude, suggesting OC decreases were not due to broader opioid interventions. Consistent with the formulation, decreases were larger for nonoral than oral abuse. Abuse-deterrent opioids may mitigate abuse and overdose risks among chronic pain patients.",

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AU - Chilcoat, H. D.

AU - Butler, S. F.

AU - Sellers, E. M.

AU - Kadakia, A.

AU - Harikrishnan, V.

AU - Haddox, J. D.

AU - Dart, R. C.

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The effect of an abuse-deterrent opioid formulation (OxyContin) on opioid abuse-related outcomes in the postmarketing setting

Abstract

ASJC Scopus subject areas

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