The effect of aminophylline on uterine smooth muscle contractility and prostaglandin production in the pregnant rat uterus in vitro

Steven A. Laifer, Ramesh B. Ghodgaonkar, Howard A. Zacur, Norman H. Dubin

Research output: Contribution to journalArticlepeer-review

Abstract

The effect of aminophylline on contractility and prostaglandin production was investigated in a 20-day pregnant rat uterus preparation in vitro. A significant decrease was observed in frequency (24,4% of control, p < 0.05) and contractile force (13.8% of control, p < 0.001) in rat uterine segments treated with aminophylline. Treated segments produced more prostaglandin E2 (139.6% of control, p < 0.001) and less prostaglandin F (73.8% of control, p < 0.001) during the 45-minute observation period. No significant difference in thromboxane B2 or 6-ketoprostaglandin F production was noted. This is the first observation of prostaglandin levels in rat uterine segments treated with aminophylline. It could not be concluded from this study whether the observed changes in prostaglandin production are directly related to the relaxant effect of aminophylline.

Original languageEnglish (US)
Pages (from-to)212-215
Number of pages4
JournalAmerican journal of obstetrics and gynecology
Volume155
Issue number1
DOIs
StatePublished - Jul 1986

Keywords

  • Aminophylline
  • pregnant rat uterus in vitro
  • prostaglandins
  • uterine contractility

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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