The effect of alum concentration on the repository and adjuvant properties of alum-precipitated antigens

Robert S. Holzman, Philip S. Norman

Research output: Contribution to journalArticle

Abstract

The alum-precipitated pyridine extracts of allergenic materials recently introduced for desensitization contain much more alum in the precipitate than is commonly used in most vaccines. A study in rabbits of the relationship of alum concentration to antigen retention and antibody responses showed that an increase in alum concentration to 30 mg. per milliliter resulted in more prolonged retention of antigen at the site of injection than is observed with mineral oil-Arlacel emulsions. When used to elicit secondary immune responses, these very persistent precipitates showed little adjwvant effect and gave antibody responses only slightly better than saline solutions of antigen. Such alum precipitates, however, may provide an even greater safety factor than oil emulsions to prevent systemic reaction to toxic antigens.

Original languageEnglish (US)
Pages (from-to)65-73
Number of pages9
JournalJournal of Allergy
Volume38
Issue number2
StatePublished - Aug 1966

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Antigens
Emulsions
Antibody Formation
Mineral Oil
Poisons
Sodium Chloride
Oils
Vaccines
aluminum sulfate
Rabbits
Safety
Injections

ASJC Scopus subject areas

  • Medicine(all)

Cite this

The effect of alum concentration on the repository and adjuvant properties of alum-precipitated antigens. / Holzman, Robert S.; Norman, Philip S.

In: Journal of Allergy, Vol. 38, No. 2, 08.1966, p. 65-73.

Research output: Contribution to journalArticle

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